白蘭
一、個(gè)人簡(jiǎn)介
白蘭，博士，副教授，碩士研究生導(dǎo)師。四川省醫(yī)學(xué)科學(xué)院·四川省人民醫(yī)院藥學(xué)部副主任藥師，香港大學(xué)訪問(wèn)學(xué)者，四川省中醫(yī)藥發(fā)展促進(jìn)會(huì)制劑專(zhuān)業(yè)委員常務(wù)委員、四川省中醫(yī)藥學(xué)會(huì)方劑學(xué)專(zhuān)業(yè)委員會(huì)委員，世界中醫(yī)藥聯(lián)合會(huì)道地藥材多維評(píng)價(jià)專(zhuān)業(yè)委員會(huì)會(huì)員，Chinese Herbal Medicines 青年編委。研究方向：中藥、天然產(chǎn)物的作用機(jī)制以及制劑轉(zhuǎn)化研究。
二、代表性成果（可含承擔(dān)項(xiàng)目、發(fā)表論文、論著、獲獎(jiǎng)等）
承擔(dān)項(xiàng)目：
（1） 四川省科技廳，2023NSFSC0685，基于靶點(diǎn)鉤釣策略探索中藥鴉膽子調(diào)控肝癌的物質(zhì)基礎(chǔ)和作用機(jī)制研究， 2023-01 至2025-12
（2） 西南特色中藥資源國(guó)家重點(diǎn)實(shí)驗(yàn)室， SKLTCM2022019，川芎及其活性成分調(diào)控衰老大鼠神經(jīng)元線(xiàn)粒體損傷作用機(jī)制研究， 2022-09至2024-08
（3） 四川省中藥管理局項(xiàng)目，2023MS222，基于衰老大鼠神經(jīng)元線(xiàn)粒體探索道地藥材川芎保護(hù)神經(jīng)元細(xì)胞的作用機(jī)制，2023-01至2025-12
（4） 四川省衛(wèi)健委，20PJ095，短肽自主裝-乳糖酸肝靶向載藥納米粒設(shè)計(jì)，2020-01至2021-12，已結(jié)題
（5） 四川省衛(wèi)健委，18PJ548，新德里金屬β-內(nèi)酰胺酶-1（NDM-1）抑制劑的設(shè)計(jì)、結(jié)構(gòu)優(yōu)化及活性研究，2019/01-2020/12，0.5萬(wàn)，已結(jié)題
（6） 院青年人才基金，2016QN08，以雷公藤甲素為先導(dǎo)靶向TFIIH蛋白亞基XPB的新型抗腫瘤藥物分子設(shè)計(jì)與活性研究，2017-01至2019-12，已結(jié)題
（7） 四川省科技廳 科技支撐計(jì)劃子課題，2015SZ0039，中醫(yī)藥特色醫(yī)院制劑的發(fā)掘、研發(fā)與質(zhì)量提升研究-一貫煎顆粒劑的研發(fā)，2015-01至2017-12，子項(xiàng)目主持，已結(jié)題
（8） 四川省衛(wèi)計(jì)委，150211，基于計(jì)算機(jī)輔助的MEK 抑制劑的設(shè)計(jì)、合成及抗腫瘤活性研究，2015-01至2016-12，已結(jié)題
代表論文：
(1) Lan Bai#, Ting Wang, Qichuan Deng, Wei Zheng, Xinyu Li , Hao Yang ,Rongsheng Tong*, Dongke Yu*, Jianyou Shi*. Dual properties of pharmacological activities and preparation excipient: Bletilla striata polysaccharides. International Journal of Biological Macromolecules 254 (2024) 127643.
(2) Yitong Tong, Xinyu Li, Qichuan Deng, Jianyou Shi*, Yibin Feng*, Lan Bai*; Advances of the small molecule drugs regulating fibroblast-like synovial proliferation for rheumatoid arthritis[J]. Frontiers in Pharmacology, 2023, 14.
(3) Qinan Yin, Liuyun Wu, Lizhu Han, Xingyue Zheng, Rongsheng Tong, Lian Li, Lan Bai*, Yuan Bian*; Immune-related adverse events of immune checkpoint inhibitors: a review [J], Front Immunol, 1411679752023
(4) Ruijie Liu, Li He, Maoyu Liu, Lu Chen, Jun Hou*, Jianyou Shi*, Lan Bai*; Erythrocyte membrane encapsulated gambogic acid nanoparticles as a therapeutic for hepatocellular carcinoma [J]. Chinese Chemical Letters, 2023, 34(1)
(5) Haoyuan Peng, Lei Zhong, Lin Cheng, Lu Chen, Rongsheng Tong, Jianyou Shi*, Lan Bai*；Ganoderma lucidum: Current advancements of characteristic components and experimental progress in anti-liver fibrosis [J]. Frontiers in Pharmacology, 2023, 13.
(6) Qi Liang, Maoyu Liu, Jian Li, Rongsheng Tong, Yonghe Hu*, Lan Bai*, Jianyou Shi*；NAE modulators: A potential therapy for gastric carcinoma [J]. European journal of medicinal chemistry, 2022, 231: 114156
(7) Bingyao Xu#, Lan Bai#, Lu Chen, Rongsheng Tong*, Yibin Feng* and Jianyou Shi*; Terpenoid natural products exert neuroprotection via the PI3K/Akt pathway [J]. Frontiers in pharmacology, 2022, 13: 1036506
(8)Qiaoqiao Hu*, Lan Bai*, Zejiang Zhu, Zhengying Su, Peng Bai, Minghai Tang, Caixia Dou, Junfeng Yan, Rongsheng Tong, Wuyu Zhang, Lijuan Chen, Lulu Cai#；β-Elemene-loaded polymeric micelles intensify anti-carcinoma efficacy and alleviate side effects, Chinese Chemical Letters,2020, 31(3):915-918
(9) Li He, Qian Su, Lan Bai*, Meifeng Li, Juanru Liu, Xiaomei Liu, Cunyan Zhang, Zhongliang Jiang, Jun He, Jianyou Shi#, Shan Huang#, Li Guo#; Recent research progress on natural small molecule bibenzyls and its derivatives in Dendrobium species, European journal of medicinal chemistry,2020,204:112530
(10) Jing Zhao, Jinqi Li, Zhongliang Jiang, Rongsheng Tong, Xingmei Duan, Lan Bai#, Jian-You Shi#;Chitosan, N,N,N-trimethyl chitosan (TMC) and 2-hydroxypropyltrimethyl ammonium chloride chitosan (HTCC): The potential immune adjuvants and nano carriers ,International journal of biological macromolecules, 2020,154:339-348
(11) Yu Zheng*, Lan Bai*, Yanping Zhou , Rongsheng Tong , Minghui Zeng c, Xiaofang Li#, Jianyou Shi#; Polysaccharides from Chinese herbal medicine for anti-diabetes recent advances, International Journal of Biological Macromolecules, 2019,121:1240-1253
(12) Lan Bai*, Xiaofang Li*, Li He, Yu Zheng, Haiying Lu, Jinqi Li, Lei Zhong, Rongsheng Tong, Zhongliang Jiang, Jianyou Shi#. Antidiabetic Potential of Flavonoids from Traditional Chinese Medicine: A Review. The American Journal of Chinese Medicine,2019,47(5):933-957
(13) Ting Wanga*, Zhuyu Xua*, Yongping Lua*, Jianyou Shi, Wenbo Liu, Chengchen Zhang, Zhongliang Jiang, Baowen Qi# and Lan Bai#, Recent Progress tort the Discovery of Sirt2 Inhibitors for the Treatment of Various Cancers, Current Topics in Medicinal Chemistry, 2019, 19(12): 1051-1058;
(14) Haiying Lu*, Lan Bai*, Yanping Zhou*, Yongping Lu, Zhongliang Jiang# and Jianyou Shi#. Recent Study of Dual HDAC/PARP Inhibitor for the Treatment of Tumor. Current topics in medicinal chemistry, 2019,19(12): 1041-1050
授權(quán)專(zhuān)利：
一種紅細(xì)胞膜包裹藤黃酸的仿生納米顆粒、制備方法及其應(yīng)用(ZL 202110905801.2)
一種欖香烯聚合物膠束制劑及其制備方法和應(yīng)用（ZL201911227311.0）