胡慧玲
一、個(gè)人簡(jiǎn)介
教授、碩士研究生導(dǎo)師、美國(guó)休斯敦大學(xué)訪問(wèn)學(xué)者、博士、博士后。
四川省海外高層次留學(xué)人才、四川省學(xué)術(shù)和技術(shù)帶頭人后備人選、國(guó)家自然科學(xué)基金委通訊評(píng)審專家、教育部學(xué)位中心評(píng)審專家、成都?xì)W美同學(xué)會(huì)?成都留學(xué)人員聯(lián)誼會(huì)第一屆理事會(huì)理事、成都中醫(yī)藥大學(xué)歐美同學(xué)會(huì)?留學(xué)人員聯(lián)誼會(huì)會(huì)員、成都中醫(yī)藥大學(xué)優(yōu)勢(shì)特色學(xué)科中藥制劑學(xué)學(xué)術(shù)帶頭人后備人選。
研究方向：（1）中藥新制劑、新劑型研究；（2）口服胃腸道釋藥系統(tǒng)研究。
2、代表性成果
承擔(dān)項(xiàng)目：
1. 2021/04-2023/04，基于“香-效”整合作用的木香精油質(zhì)量標(biāo)準(zhǔn)提升及大健康產(chǎn)品開發(fā)研究，四川省科技廳重點(diǎn)研發(fā)項(xiàng)目，負(fù)責(zé)人
2. 2021/12-2023/12，四川省2021-2023年“三區(qū)”人才支持計(jì)劃科技人員專項(xiàng)計(jì)劃，四川省科技廳，負(fù)責(zé)人
3. 2019/09-2022/08，黑水縣當(dāng)歸全產(chǎn)業(yè)鏈開發(fā)應(yīng)用示范，四川省科技廳重點(diǎn)研發(fā)項(xiàng)目，主研
4. 2019/01-2021/12，基于“丸劑特征-整合藥動(dòng)-機(jī)體應(yīng)答”的附子理中丸“去性存用”作用機(jī)制研究，國(guó)家自然科學(xué)基金青年基金，主研
5. 2015/01-2018/12，基于體內(nèi)分布及機(jī)體應(yīng)答部位差異性的川木香煨制與歸經(jīng)趨向相關(guān)性研究，國(guó)家自然科學(xué)基金面上項(xiàng)目，負(fù)責(zé)人
6. 2014/01-2017/12，四逆湯藥味配伍‘毒減而效不減的機(jī)制研究’，國(guó)家自然科學(xué)基金面上項(xiàng)目，主研
7. 2014/01-2016/12，基于‘組分-藥效-靶點(diǎn)’作用網(wǎng)絡(luò)研究四物湯制備工藝環(huán)節(jié)評(píng)價(jià)模式，國(guó)家自然科學(xué)基金青年基金，主研
8. 2011/01-2013/12，從胃腸吸收及部位差異性角度研究川木香煨制前后功效變化的藥動(dòng)學(xué)基礎(chǔ)，國(guó)家自然科學(xué)基金青年基金，負(fù)責(zé)人
9. 2007/07-2009/07，川木香煨制前后藥效成分變化與藥理作用相關(guān)性研究，四川省科技廳應(yīng)用基礎(chǔ)，負(fù)責(zé)人
發(fā)表論文、論著、獲獎(jiǎng)等：
1. Chunlei Wei, Jing Qiu, Yuyi Wu, Ziqiang Chen, Ziwei Yu, Zecheng Huang, Ke Yang, Huiling Hu* , Fang Liu*. Promising traditional Chinese medicine for the treatment of cholestatic liver disease process (cholestasis, hepatitis, liver fibrosis, liver cirrhosis).Journal of Ethnopharmacology, 297 (2022) 115550
2. Zecheng Huang, Chunyi Xu, Linxian Zhao, Chunlei Wei, Yuyi Wu, Jing Qiu ,Ziwei Yu, Ke Yang, Huiling Hu*, Zhanguo Wang*.Journal of Drug Delivery Science and Technology, 78 (2022) 103942
3. Ke Yang, Jing Qiu, Zecheng Huang, Ziwei Yu, Wenjun Wang, Huiling Hu* , Yu You **. A comprehensive review of ethnopharmacology, phytochemistry, pharmacology, and pharmacokinetics of Schisandra chinensis (Turcz.) Baill. and Schisandra sphenanthera Rehd. et Wils.Journal of Ethnopharmacology，284 (2022) 114759
4. Yuyi Wu#，Wenjun Wang#, Ziwei Yu, Ke Yang, Zecheng Huang, Ziqiang Chen, Xiaomin Yan, Huiling Hu*, Zhanguo Wang*. Biomaterials Advances, 2022，136：212798
5. Ziqiang Chen, Chunlei Wei, Ziwei Yu, Ke Yang, Zecheng Huang, Huiling Hu*,Zhan-guo Wang*.An effective method for preventing cholestatic liver injury of Aucklandiae Radix and Vladimiriae Radix: Inflammation suppression and regulate the expression of bile acid receptors. Journal of Ethnopharmacology, 294(2022)115330
6. Ziwei Yu, Ziqiang Chen, Qijuan Li, Ke Yang，Zecheng Huang，Wenjun Wang, Siyu Zhao, Huiling Hu*. What dominates the changeable pharmacokinetics of natural sesquiterpene lactones and diterpene lactones: a review focusing on absorption and metabolism. Drug Metabolism Reviews, 2021,53(1):122-140
7. Ziwei Yu, Yu Xie，Ze-Cheng Huang; Ke Yang; Zhan-Guo Wang; Huiling Hu*.Study of the therapeutic effect of raw and processed Vladimiriae Radix on ulcerative colitis based on intestinal flora, metabolomics and tissue distribution analysis. Phytomedicine, 2021 (85), 153538
8. Xiaomin Yan, Zecheng Huang, Yuyi Wu, Ziwei Yu, Ke Yang, Ziqiang Chen, Wenjun Wang, Huiling Hu,*, Zhanguo Wang*. Sequential loading of inclusion complex/nanoparticles improves the gastric retention of Vladimiriae Radix essential oil to promote the protection of acute gastric mucosal injury. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 610 (2021) 121234
9. Zecheng Huang, Chunlei Wei, Ke Yang, Ziwei Yu, Zhanguo Wang, Huiling Hu*. Aucklandiae Radix and Vladimiriae Radix: A systematic review in ethnopharmacology, phytochemistry and pharmacology. Journal of Ethnopharmacology,2021,114372
10. Wenjun Wang, Qijuan Li, Xiaomin Yan, Ziqiang Chen, Yu Xie, Huiling Hu?, Zhanguo Wang?. Comparative study of raw and processed Vladimiriae Radix on pharmacokinetic and anti-acute gastritis effect through anti-oxidation and anti-inflammation. Phytomedicine, 2020, 70:153224
11. Yan Xiaomin, Wang Wenjun, Chen Ziqiang, Xie Yu, Li Qijuan, Yu Ziwei, Hu Huiling*, Wang Zhanguo* . Quality assessment and differentiation of Aucklandiae Radix and Vladimiriae Radix based on GC-MS fingerprint and chemometrics analysis: basis for clinical application. Analytical and Bioanalytical Chemistry, 2020, 412 (7): 1535-1549
12. Ziqiang Chen, Qijuan Li, Ziwei Yu, Xiaomin Yan, Wenjun Wang, Yu Xie, Huiling Hu? ,Zhanguo Wang?.Analysis of the similarities and differences between Auclandia and Vladimirae rhizomes by chemical profiling and chemometric analysis. Journal of Ethnopharmacology, 255 (2020) 112719
13. Qijuan Li, ZhanguoWang, Yu Xie, Huiling Hu?. Antitumor activity and mechanism of costunolide and dehydrocostus lactone: Two natural sesquiterpene lactones from the Asteraceae family. BIOMEDICINE & PHARMACOTHERAPY, 2020, 125:109955
14. 王文俊，嚴(yán)曉敏，陳自強(qiáng)，李奇娟，謝余，胡慧玲*，王戰(zhàn)國(guó)*. 木香烴內(nèi)酯與去氫木香內(nèi)酯共包封聚乙二醇化長(zhǎng)循環(huán)脂質(zhì)體的制備及表征. 中草藥，2019，50（17）：4068-4075
15. 胡慧玲,傅超美*,趙萱*,章津銘,高飛,何瑤,傅舒,李玲.中藥制劑“毒與效”的整合探析.中國(guó)中藥雜志,2016,41（18）：3483-3489
16. 胡慧玲（5/8），中藥制劑共性技術(shù)--制粒關(guān)鍵技術(shù)及產(chǎn)業(yè)化應(yīng)用，四川省科技廳，四川省科學(xué)技術(shù)進(jìn)步獎(jiǎng)，二等獎(jiǎng)，2016
17. 《中藥藥劑學(xué)》，編委，中國(guó)中醫(yī)藥出版社，2021
18. 《中藥藥劑學(xué)實(shí)驗(yàn)雙語(yǔ)教材》，副主編，中國(guó)醫(yī)藥科技出版社，2020
19. 《中藥新藥研發(fā)學(xué)》，編委，中國(guó)中醫(yī)藥出版社，2017
20. 《中藥提取工藝學(xué)》, 編委，人民衛(wèi)生出版社，2014