李小芳
一、個人簡介
李小芳，博士、教授、博士研究生導(dǎo)師、博士后合作導(dǎo)師，成都中醫(yī)藥大學優(yōu)勢特色學科藥劑學學科帶頭人。四川省高等學?！罢n程思政”示范課《中藥提取工藝學》教學團隊負責人。
為國家中醫(yī)藥考試命審題專家、國家自然科學基金委同行評議專家、國家衛(wèi)健委醫(yī)藥衛(wèi)生科技發(fā)展中心科研項目評審專家、教育部學位中心評審專家、四川省院士（專家）工作站專家、四川省科技計劃項目評審專家、四川省科技成果獎勵評審專家、四川省藥品注冊現(xiàn)場核查專家、四川省醫(yī)療保障專家?guī)鞂＜?、北京市自然科學基金評審專家、河北省科技計劃項目評審專家。尚任中華中醫(yī)藥學會中藥制劑分會常務(wù)委員、世界中醫(yī)藥學會聯(lián)合會道地藥材多維評價專業(yè)委員會常務(wù)理事、成都市藥學會第八屆藥劑專業(yè)委員會副主任委員等學術(shù)職務(wù)。
長于中藥新藥、中藥制劑關(guān)鍵技術(shù)及中藥新型遞藥系統(tǒng)等領(lǐng)域的研究。作為負責人和主研人員承擔了國家“十五”科技攻關(guān)項目、國家自然科學基金項目、科技部863項目、國家“十一五”科技支撐計劃以及部省級、廳局級課題共40余項；作為主研參與并取得具有代表性的科研成果有藿香正氣液的研制、太極通天液的研制，均獲生產(chǎn)批文，已上市?！稗较阏龤饪诜旱闹苽浞椒ā庇?997年獲中國專利發(fā)明金獎，為國內(nèi)首次獲此殊榮的中藥產(chǎn)品。
公開發(fā)表學術(shù)論文200余篇， SCI論文50余篇，其中多篇入選ESI藥理學與毒理學學科高水平論文及高被引論文。
主編、副主編《中藥藥劑學》、《中藥藥劑學實驗》雙語教材、《藥劑學》、《中藥提取工藝學》、《中藥制藥工藝學》等國家規(guī)劃教材10余部。以第一發(fā)明人申請國家發(fā)明專利12項，已授權(quán)8項；獲四川省及成都市科技進步獎6項。
已為國家培養(yǎng)碩、博士研究生90余名。
三、代表性成果
1.Chen, Huijuan; Deng, Mao; Xie, Long; Liu, Kai; Zhang, Xumin; Li, Xiaofang. Preparation and characterization of quercetin nanosuspensions using gypenosides as novel stabilizers. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY. 2022, 67.
2.Deng, Mao; Chen, Huijuan; Xie, Long; Liu, Kai; Zhang, Xumin; Li, Xiaofang. Tea saponins as natural emulsifiers and cryoprotectants to prepare silymarin nanoemulsion. LWT-FOOD SCIENCE AND TECHNOLOGY. 2022, 156.
3.Zheng, Yu; Zhao, Yuxin; Bai, Mengting; Gu, Huan; Li Xiaofang. Metal-organic frameworks as a therapeutic strategy for lung diseases. J Mater Chem B. 2022, 10(30):5666-5695.
4.Lu, Jing; Xie, Long; Wu, Anxin; Wang, Xian; Liang, Youdan; Dai, Xiaolin; Cao, Yi; Li, Xiaofang. Delivery of silybin using a zein-pullulan nanocomplex: Fabrication, characterization, in vitro release properties and antioxidant capacity. COLLOIDS AND SURFACES B-BIOINTERFACES. 2022, 217.
5.謝青璇, 李小芳, 謝龍,王嫻,曹怡,梁由單. Box-Behnken效應(yīng)面法優(yōu)化大黃素/小檗堿-殼聚糖雙載藥納米粒的處方工藝研究[J]. 中草藥, 2021, 52(6):9.
6.龍家英,李小芳,王嫻,鄧茂,古環(huán),謝龍,陳慧娟,代小琳.茶皂素用于穩(wěn)定橙皮苷納米混懸劑及其機制研究[J].藥學學報. 2021,56(11).
7.Cao Yi, Xie Long, Liu Kai, et al. The antihypertensive potential of flavonoids from Chinese Herbal Medicine: A review[J]. Pharmacological Research. 2021,174.
8.Liu Kai, Zhang Xumin, Xie Long, et al. Lupeol and its derivatives as anticancer and anti-inflammatory agents: molecular mechanisms and therapeutic efficacy[J]. Pharmacological Research, 2021,164.
9.Jiawen Song, Jiaying Long, Long Xie, Qiang Sun, Linlin Zhang, Huijuan Chen, Mao Deng, Xiaofang Li, Solubilization and changes of physicochemical properties of baicalin by nano sponge, and toxicity of zebrafish liver, Journal of Drug Delivery Science and Technology. 2020, 60.
10.Jiaying Long, Jiawen Song, Xumin Zhang, Mao Deng, Long Xie, Linlin Zhang, Xiaofang Li. Tea saponins as natural stabilizers for the production of hesperidin nanosuspensions [J]. International Journal of Pharmaceutics. 2020, 583.
11.Chengying Shen, Junjun Zhu, Jiawen Song, Jing Wang, Baode Shen, Hailong Yuan, Xiaofang Li. Formulation of Pluronic F127/TPGS Mixed Micelles toImprove the Oral Absorption of Glycyrrhizic Acid. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. 2020, 46(7):1100-1107.
12. Ren, Guilin; Zhong, Yu; Ke, Gang; Liu, Xiaoli; Li, Huiting; Li, Xiaofang; Zheng, Qin; Yang, Ming. The Mechanism of Compound Anshen Essential Oil in the Treatment of Insomnia Was Examined by Network Pharmacology[J]. Evidence -Based Complementary and Alternative Medicine. 2019, 2019.
13. Zhao, Tiantian; Tang, Hailong; Xie, Long; Zheng, Yu; Ma, Zubing; Sun, Qiang; Li, Xiaofang. Scutellaria baicalensis Georgi. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology[J]. Journal of Pharmacy and Pharmacology. 2019,71(9):1353–1369.
14.Yu Zheng, Lan Bai, Yanping Zhou, Rongsheng Tong, Minghui Zeng, Xiaofang Li, Jianyou Shi. Polysaccharides from Chinese herbal medicine for anti-diabetes recent advances[J]. International Journal of Biological Macromolecules, 2019, 121: 1240–1253.
15.Chengli Ling, Jianming Liang, Chun Zhang, Ruixiang Li, Qianqian Mou, Jin Qin, Xiaofang Li, Jianxin Wang. Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury[J]. Molecules 2018, 23(3):564.