龔其海
一、個(gè)人簡(jiǎn)介
龔其海，醫(yī)學(xué)博士、二級(jí)教授，兼職博士研究生導(dǎo)師。貴州省優(yōu)秀青年科技人才，貴州省高層次創(chuàng)新人才“百”層次人才，教育部新世紀(jì)優(yōu)秀人才，貴州省省管專家?，F(xiàn)任貴州省基礎(chǔ)藥理重點(diǎn)實(shí)驗(yàn)室、基礎(chǔ)藥理教育部重點(diǎn)實(shí)驗(yàn)室暨特色民族藥教育部國(guó)際合作聯(lián)合實(shí)驗(yàn)室主任，貴州省中藥民族藥2011協(xié)同創(chuàng)新中心主任，中國(guó)藥理學(xué)會(huì)第十二屆理事會(huì)理事，中國(guó)藥理學(xué)會(huì)中藥與天然藥物藥理專業(yè)委員會(huì)委員，《中藥藥理與臨床》編委，《遵義醫(yī)科大學(xué)學(xué)報(bào)》副主編。
研究方向?yàn)橹兴幩幚韺W(xué)與毒理學(xué)，先后完成貴州道地中藥材淫羊藿、天麻主要有效成分淫羊藿苷、天麻素等用于防治老年癡呆、缺血性腦卒中等的研究及黔產(chǎn)木姜葉柯甜茶綜合開發(fā)利用關(guān)鍵技術(shù)研究。主持（完成）國(guó)家重點(diǎn)研發(fā)計(jì)劃、國(guó)家自然科學(xué)基金等國(guó)家級(jí)課題5項(xiàng)，省部級(jí)項(xiàng)目20項(xiàng)，以第一作者或通訊作者發(fā)表SCI論文58篇，已培養(yǎng)碩士30名，在讀碩士生9名，博士1名，在讀博士生3名。已轉(zhuǎn)讓國(guó)家發(fā)明專利2項(xiàng)，獲貴州省科技進(jìn)步一等獎(jiǎng)1項(xiàng)、二等獎(jiǎng)2項(xiàng)，三等獎(jiǎng)1項(xiàng)。先后獲貴州省青年科技獎(jiǎng)、貴州省優(yōu)秀教師、貴州省優(yōu)秀碩士生導(dǎo)師、中國(guó)藥學(xué)會(huì)藥學(xué)期刊優(yōu)秀論文獎(jiǎng)、中國(guó)藥理學(xué)會(huì)SERVIER青年藥理工作者獎(jiǎng)、西部藥學(xué)之星、貴州青年“五四”獎(jiǎng)?wù)录百F州省優(yōu)秀黨務(wù)工作者等表彰，帶領(lǐng)的團(tuán)隊(duì)先后入選貴州省科技創(chuàng)新人才團(tuán)隊(duì)、教育部創(chuàng)新團(tuán)隊(duì)（包括“滾動(dòng)”支持），享受國(guó)務(wù)院特殊津貼。
二、代表性成果
1. Jianmei Gao, Congjian Ma, Dianya Xia, Nana Chen, Jianyong Zhang, Fan Xu, Fei Li, Yuqi He, Qihai Gong*. Icariside II preconditioning evokes robust neuroprotection against ischaemic stroke, by targeting Nrf2 and the OXPHOS/NF-κB/ferroptosis pathway. Br J Pharmacol. 2023;180(3):308-329.
2. Jianmei Gao, Xun Zhang, Guotao Shu, Nana Chen, Jianyong Zhang, Fan Xu, Fei Li, Yuangui Liu, Yu Wei, Yuqi He, Jingshan Shi, Qi-hai Gong*. Trilobatin rescues cognitive impairment of Alzheimer's disease by targeting HMGB1 through mediating SIRT3/SOD2 signaling pathway. Acta Pharmacol Sin. 2022, 43: 2482–2494.
3. Yiqi Li, Yeli Li, Nana Chen, Linying Feng, Jianmei Gao , Nan Zeng, Zhixu He, Qihai Gong*.Icariside II Exerts Anti-Type 2 Diabetic Effect by Targeting PPARα/γ: Involvement of ROS/NF-κB/IRS1 Signaling Pathway. Antioxidants (Basel). 2022;11(9):1705.
4. Yeli Li, Linying Feng, Dianyou Xie, Mu Lin,Yiqi Li, Nana Chen, Danli Yang, Jianmei Gao,Yizhun Zhu, QihaiGong*. Icariside II, a naturally-occurring SIRT3 agonist, rescues myocardial infarction through AMPK/PGC-1α/apoptosis signaling pathway. Antioxidants (Basel). 2022;11(8):1465.
5. Fengying Huang, Lingyu Luo, Yujia Wu, Dianya Xia, Fan Xu, Jianmei Gao, Jingshan Shi, Qihai Gong*.Trilobatin promotes angiogenesis after cerebral ischemia-reperfusion injury via SIRT7/VEGFA signaling pathway in rats. Phytother Res. 2022;36(7):2940-2951.
6. Li Na, Li Xi, Shi Yan-Ling, Gao Jian-Mei, He Yu-Qi, Li Fei, Shi Jing-Shan, Gong Qi-Hai*.Trilobatin, a Component from Lithocarpus polystachyrus Rehd., Increases Longevity in C. elegans Through Activating SKN1/SIRT3/DAF16 Signaling Pathway. Front Pharmacol . 2021;12:655045.
7. Jianmei Gao, Long Long, Fan Xu, Linying Feng,Yuangui Liu, Jingshan Shi, Qihai Gong*. Icariside II, a phosphodiesterase 5 inhibitor, attenuates cerebral ischemia/reperfusion injury by inhibiting GSK-3β-mediated activation of autophagy. Br J Pharmacol. 2020 Mar;177(6):1434-1452.
8. Jianmei Gao, Wei Wang, Na Li, Nana Chen, Fan Xu, Jingshan Shi, Qihai Gong*.Neuroprotective effects of trilobatin, a novel naturally-occurring Sirt3 agonist from Lithocarpus polystachyus Rehd., mitigates cerebral ischemia/reperfusion injury: Involvement of TLR4/NF-κB and Nrf2/ Keap-1 signaling. Antioxid Redox Signal. 2020;33(2):117-143.
9. Yong Zheng, Yan Deng, Jian-Mei Gao, Chun Lv, Ling-Hu Lang, Jing-Shan Shi, Chang-Yin Yu*, Qi-Hai Gong*.Icariside II inhibits lipopolysaccharide-induced inflammation and amyloid production in rat astrocytes by regulating IKK/IκB/NF-κB/BACE1 signaling pathway. Acta Pharmacol Sin. 2020 Feb;41(2):154-162.
10. Mu-Bo Liu, Wei Wang, Jian-Mei Gao, Fei Li, Jing-Shan Shi, Qi-Hai Gong*.Icariside II Attenuates Cerebral Ischemia/Reperfusion-Induced Blood-Brain Barrier Dysfunction in Rats via Regulating the Balance of MMP9/TIMP1. Acta Pharmacol Sin. 2020 ;41(12):1547-1556.