王平
一、個人簡介
王平，碩士、副教授。主要研究方向為計算生物學模型識別清熱藥中化合物藥效或毒效的反應程度，主要使用分子動力學、分子模擬、藥效學-藥動學聯(lián)合模型、組學的圖算法等工具開展相應工作。目前研究興趣在于尋找和使用識別雙分子組合藥效或毒效改變趨勢的研究方法，以解釋相關配伍機理。近年來初步實現(xiàn)了對單一化合物的相關模型構建，發(fā)表相關研究論文41篇。
二、代表性成果
[1]蔣晴,羅煜,朱正文,梁雨生,吳嘉思,蘇絲雨,曾勇,孟憲麗,王平*. 基于中效方程的黃芩苷與小檗堿抗炎協(xié)同作用研究[J]. 中國藥理學通報, 2020, 36(03):443-444.
[2]王麗,胡櫻凡,童東,左芳,魏志成,孟憲麗,王平*. 黃連堿對內毒素發(fā)熱大鼠解熱作用的PK-PD研究[J]. 中國藥理學通報, 2017,33(04):552-556.
[3]于宜平,張艷,李紅,王平*,孟憲麗,陳小睿,曾勇. 黃芩苷對角叉菜膠致熱大鼠解熱作用的PK-PD模型研究[J]. 中草藥, 2014, 45(04):527-531.
[4]李紅,張艷,于宜平,王平*,李帆帆,孟憲麗. 大黃解熱作用與降低血漿一氧化氮作用的PK-PD研究[J].中國中藥雜志, 2013, 38(08):1231-1236.
[5]劉宇,楊娟,陀揚凌,韋婷,曾勇,王平*,孟憲麗. 沙棘膏中槲皮素、山柰素、異鼠李素血藥濃度的HPLC-MS/MS測定及大鼠體內藥代動力學研究[J]. 中國中藥雜志, 2015, 40(19):3859-3865.
[6]Li Xiang,Youdong Xu,Yan Zhang,Xianli Meng,Ping Wang*. Virtual screening studies of Chinese medicine Coptidis Rhizoma as alpha7 nicotinic acetylcholine receptor agonists for treatment of Alzheimer’s disease[J]. Journal of Molecular Structure, 2015, 1086.
[7]Li Xiang, Ying-Fan Hu，Jia-Si Wu, Li Wang, Wen-Ge Huang, Chen-Si Xu, Xian-Li Meng*, Ping Wang*. Semi-Mechanism-Based Pharmacodynamic Model for the Anti-Inflammatory Effect of Baicalein in LPS-Stimulated RAW264.7 Macrophages. Front Pharmacol. 2018 Jul 18;9:793. doi: 10.3389/fphar.2018.00793. eCollection 2018.
[8]Yingfan Hu, Li Wang, Li Xiang, Jiasi Wu, Wen’ge Huang, Chensi Xu, Xianli Meng, Ping Wang*. Pharmacokinetic-Pharmacodynamic Modeling for Coptisine Challenge of Inflammation in LPS-Stimulated Rats. Sci Rep. 2019;9(1):1450. Published 2019 Feb 5. doi:10.1038/s41598-018-38164-4
[9]Liang Zou, Yan Zhang, Wei Li, Jinming Zhang, Dan Wang, Jia Fu*, Ping Wang*. Comparison of Chemical Profiles, Anti-Inflammatory Activity, and UPLC-Q-TOF/MS-Based Metabolomics in Endotoxic Fever Rats between Synthetic Borneol and Natural Borneol. Molecules. 2017;22(9):1446. Published 2017 Aug 31. doi:10.3390/molecules22091446
[10]Wen'ge Huang, Yingzhuo Yang, Wen Wen, Yu Luo, Jiasi Wu, Li Xiang, Yinfan Hu, Shijun Xu, Simin Chen*, Ping Wang*. Vanillin enhances the passive transport rate and absorption of drugs with moderate oral bioavailability in vitro and in vivo by affecting the membrane structure. Food Funct. 2020;11(1):700-710. doi:10.1039/c9fo02846c
[11]Yu Luo, Qing Jiang, Zhengwen Zhu, Haseeb Sattar, Jiasi Wu, Wenge Huang, Siyu Su, Yusheng Liang, Ping Wang *, Xianli Meng*. Phosphoproteomics and Proteomics Reveal Metabolism as a Key Node in LPS-Induced Acute Inflammation in RAW264.7 [published online ahead of print, 2020 Jun 2]. Inflammation. 2020;10.1007/s10753-020-01240-x. doi:10.1007/s10753-020-01240-x
[12]Boyang Hu, Hai Zhang, Xianli Meng, Fei Wang*, Ping Wang*. Aloe-emodin from rhubarb (Rheum rhabarbarum) inhibits lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages. J Ethnopharmacol. 2014;153(3):846-853. doi:10.1016/j.jep.2014.03.059