曾南
一、個(gè)人簡(jiǎn)介
曾南,中共黨員,博士,日本名古屋大學(xué)博士后,教授,碩、博士生導(dǎo)師,成都中醫(yī)藥大學(xué)藥學(xué)院中藥藥理系主任,為黨的十九大代表、四川省優(yōu)秀共產(chǎn)黨員。熱愛(ài)中醫(yī)藥事業(yè),愛(ài)崗敬業(yè),立德樹(shù)人,從事中藥藥理學(xué)、藥理學(xué)教學(xué)和科研工作,先后獲得四川省優(yōu)秀留學(xué)回國(guó)人員、四川省有突出貢獻(xiàn)的優(yōu)秀專(zhuān)家、四川省中醫(yī)藥管理局學(xué)術(shù)帶頭人、四川省三八紅旗手標(biāo)兵、省部級(jí)領(lǐng)軍人才計(jì)劃等稱(chēng)號(hào)。兼任四川省藥理學(xué)學(xué)會(huì)副會(huì)長(zhǎng)、四川省藥學(xué)會(huì)藥理與臨床藥理分委員會(huì)委員及成都藥學(xué)會(huì)藥理學(xué)專(zhuān)業(yè)委員會(huì)副主任委員。開(kāi)展中藥藥理與毒理學(xué)研究工作,主要方向?yàn)橹兴幙寡酌庖?、中藥抗抑郁等作用及機(jī)制研究,研究成果具有重要的應(yīng)用價(jià)值和明顯的學(xué)術(shù)影響。主持各級(jí)科研課題20余項(xiàng),其中國(guó)家級(jí)4項(xiàng)、部省級(jí)5項(xiàng),獲四川省科技進(jìn)步二等獎(jiǎng)2項(xiàng)、三等獎(jiǎng)3項(xiàng);以1作及通訊作者身份發(fā)表學(xué)術(shù)論文170余篇,其中SCI收錄40余篇;獲國(guó)家發(fā)明專(zhuān)利授權(quán)5項(xiàng)。主編、副主編學(xué)術(shù)著作及教材10余部,獲四川省教育教學(xué)成果一等獎(jiǎng)2項(xiàng)、二等獎(jiǎng)1項(xiàng)。培養(yǎng)60余名博、碩士研究生。參與企業(yè)新藥研發(fā)20余項(xiàng),其中已上市品種13個(gè),產(chǎn)生了良好的經(jīng)濟(jì)和社會(huì)效益。
二、代表性成果(可含承擔(dān)項(xiàng)目、發(fā)表論文、論著、獲獎(jiǎng)等)
承擔(dān)項(xiàng)目
1. 國(guó)家自然科學(xué)基金:基于“溫通心陽(yáng)”功效桂枝抗非菌性炎癥反應(yīng)DAMPs-NLRP3/GSDMD通路機(jī)制研究(82074094),負(fù)責(zé)人,2021-2024
2. 國(guó)家自然科學(xué)基金:桂枝、荊芥揮發(fā)油抗炎效應(yīng)的NLRP3炎癥小體通路機(jī)制研究(81473399),負(fù)責(zé)人,2015-2018
3. 國(guó)家自然科學(xué)基金:桂枝、荊芥揮發(fā)油抗病毒效應(yīng)的TLR/IFN信號(hào)機(jī)制研究(30973923),負(fù)責(zé)人,2010-2012
4. 四川省科技廳:中藥藥理四川省青年科技創(chuàng)新研究團(tuán)隊(duì)(2014TD0007),負(fù)責(zé)人,2014-2016
發(fā)表論文
1. Structural diversity and bioactivity of polysaccharides from medicinal mushroom Phellinus spp.: A review. Food Chemistry, 397 (2022) 133731.
2. JFNE-A isolated from Jing-Fang n-butanol extract attenuates lipopolysaccharide-induced acute lung injury by inhibiting oxidative stress and the NF-κB signaling pathway via promotion of autophagy. Phytomedicine ,2021,12; 96 (2022) 153891.
3. Xiaoyaosan ethyl acetate fraction alleviates depression-like behaviors in CUMS mice by promoting hippocampal neurogenesis via modulating the IGF-1Rβ/PI3K/Akt signaling pathway. J Ethnopharmacol. 2022 Jan 17; 288:115005.
4. Alpinetin: A Review of Its Pharmacology and Pharmacokinetics. Front Pharmacol. 2022 Feb 4; 13:814370.(高被引)
5. Cinnamic acid preserves against myocardial ischemia/reperfusion injury via suppression of NLRP3/Caspase-1/GSDMD signaling pathway. Phytomedicine. 2022 Jun; 100: 154047. https://pubmed.ncbi.nlm.nih.gov/35320770/.
6. Cardioprotective effect of cinnamaldehyde pretreatment on ischemia/ reperfusion injury via inhibiting NLRP3 inflammasome activation and gasdermin D mediated cardiomyocyte pyroptosis. Chemico-Biological Interactions,368 (2022) 110245, 29 October 2022
7. Extraction, purification, structural characteristics and biological properties of the polysaccharides from Codonopsis pilosula: A review. Carbohydr Polym. 2021,Jun,1;261:117863.
8. Xiaoyao Pills Ameliorate Depression-like Behaviors and Oxidative Stress Induced by Olfactory Bulbectomy in Rats via the Activation of the PIK3CA-AKT1-NFE2L2/BDNF Signaling Pathway. Front Pharmacol.2021 Apr 15; 12: 643456. https://doi.org/10.3389/fphar.2021.643456.
9. Inhibition of herpes simplex virus 1 by cepharanthine via promoting cellular autophagy through up-regulation of STING/TBK1/P62 pathway. Antiviral Res. 2021 Jul 22: 105143.
10. Cardioprotective activity of ethyl acetate extract of Cinnamomi Ramulus against myocardial ischemia/reperfusion injury in rats via inhibiting NLRP3 inflammasome activation and pyroptosis. Phytomedicine. 2021, 93, 153798. Erratum in: Phytomedicine. 2021, 95, 153863.
論著
1. 主編.逍遙散現(xiàn)代研究與應(yīng)用,人民衛(wèi)生出版社,北京,2011-08
2. 主編.藥理學(xué)(全國(guó)普通高等中醫(yī)藥院校藥學(xué)類(lèi)“十三五”規(guī)劃教材)(第2版),中國(guó)醫(yī)藥科技出版社,北京,2018-08
3. 主編.藥理學(xué)實(shí)驗(yàn)(全國(guó)普通高等中醫(yī)藥院校藥學(xué)類(lèi)“十三五”規(guī)劃教材)(第2版),中國(guó)醫(yī)藥科技出版社,北京,2018-08
4. 副主編.中藥藥理學(xué)(國(guó)家衛(wèi)生健康委員會(huì)“十四五”規(guī)劃教材,全國(guó)高等中醫(yī)藥教育教材),人民衛(wèi)生出版社,北京,2022-01
獲獎(jiǎng)
1. 四川省人民政府,省部級(jí)科技進(jìn)步(成果)三等獎(jiǎng),厚樸降低遠(yuǎn)志胃腸毒性的生物學(xué)機(jī)制與應(yīng)用開(kāi)發(fā)研究,第三完成人,2016
2. 中華中醫(yī)藥學(xué)會(huì),中華中醫(yī)藥學(xué)會(huì)科學(xué)技術(shù)獎(jiǎng).政策研究一等獎(jiǎng),基于中醫(yī)藥國(guó)際發(fā)展的中藥歐盟注冊(cè)政策研究與應(yīng)用實(shí)踐, 第五完成人,2020
3. 四川省人民政府,四川省高等教育教學(xué)成果一等獎(jiǎng),中藥學(xué)“本碩博”一體化貫通式創(chuàng)新人才培養(yǎng)模式的構(gòu)建與實(shí)踐,第六完成人,2021