謝曉芳
一、個人簡介
謝曉芳，博士，副研究員，碩士研究生導(dǎo)師，西南特色中藥資源國家重點實驗室教師。任世界中醫(yī)藥學(xué)會聯(lián)合會道地藥材多維評價專業(yè)委員會理事，中華中醫(yī)藥學(xué)會方藥量效研究分會委員、四川省環(huán)境誘變劑學(xué)會理事、四川省實驗動物學(xué)會理事。
主講本科課程《中藥毒理學(xué)》、《藥理學(xué)實驗》、《系統(tǒng)中藥學(xué)》；研究生課程《中藥毒理學(xué)專論》、《現(xiàn)代藥理研究方法與實踐》。研究方向：中藥藥效和毒理應(yīng)用研究。近年來先后承擔(dān)四川省科技廳、四川省中醫(yī)藥管理局等項目6項，參研國家自然科學(xué)基金重大、重點項目、國家科技支撐計劃項目、國家“973”計劃等項目20余項，參研完成中藥復(fù)方新藥品種7個，獲四川省科技進步獎一等獎1項（排名第9）、教育部高等學(xué)校研究優(yōu)秀成果獎（科學(xué)技術(shù)）科技進步二等獎1項（排名第3）、華夏醫(yī)學(xué)科技進步二等獎1項（排名第4），公開發(fā)表學(xué)術(shù)論文140余篇，其中第一作者或通訊作者50篇，參編著作和教材12部。
二、代表性成果
1. Xin Xu#, Xiaofang Xie#, Huiqiong Zhang, Pei Wang, Gangmin Li, Junren Chen, Guanru Chen, Xiaoyu Cao, Liang Xiong, Fu Peng*, Cheng Peng*. Water-soluble alkaloids extracted from Aconiti Radix lateralis praeparata protect against chronic heart failure in rats via a calcium signaling pathway. Biomed Pharmacother. 2021, 135: 111184.
2. Liu Xingyu, Xie Xiaofang*, Luo Maozhu, Zhao Yuting, Li Mengting, Peng Fu*, Peng Cheng*. The synergistic compatibility mechanisms of fuzi against chronic heart failure in animals: A systematic review and meta-analysis. Frontiers in Pharmacology, 2022,13. DOI: 10.3389/fphar.2022. 954253
3. Chen, Guanru#, Xie, Xiaofang#, Peng, Fu*, Wang, Tianzhixin, Chen, Junren, Li, Gangmin, Liu, Juan, Peng, Cheng*. Protective effect of the combination of essential oil from patchouli and tangerine peel against gastric ulcer in rats. Journal of Ethnopharmacology, 2021, 282:114645
4. Mengting Li#, Xiaofang Xie#, Haimei Chen, Qiuyun Xiong, Rongsheng Tong, Cheng Peng*, Fu Peng*. Aconitine induces cardiotoxicity through regulation of calcium signaling pathway in zebrafish embryos and in H9c2 cells. J Appl Toxicol. 2020, 40(6): 780-793.
5. Gang Min Li#, Jun Ren Chen#, Hui Qiong Zhang, Chen Sun 2, Guan Ru Chen, Qiu Yun Xiong, Xiao Yu Cao, Lei Yu, Zi Wei Lin, Jun Yuan Qin, Liu Jun Wu, Jing Li, Lin Pu, Fu Peng*, Xiao Fang Xie*, Cheng Peng*. Rhein activated Fas-induced apoptosis pathway causing cardiotoxicity in vitro and in vivo. Toxicol Lett., 2022, 363: 67-76.
6. Xin Xu#, Xiao-Fang Xie#,Yan-Hong Dong, Hui-Qiong Zhang, Cheng Peng*. Ginsenoside Rg1 Reduces Cardiotoxicity While Increases Cardiotonic Effect of Aconitine in vitro. Chin J Integr Med. 2022, 28(8): 693-701.
7. Huiqiong Zhang#, Xiaofang Xie#, Gangmin Li, Junren Chen, Mengting Li, Xin Xu, Qiuyun Xiong, Guanru Chen, Yanpeng Yin, Fu Peng*, Yan Chen, Cheng Peng*. Erianin inhibits human lung cancer cell growth via PI3K/Akt/mTOR pathway in vitro and in vivo. Phytotherapy Research, 2021, 35: 4511-4525.
8. Junren Chen, Gangmin Li, Chen Sun, Fu Peng*, Lei Yu, Yan Chen, Yuzhu Tan, Xiaoyu Cao, Yunli Tang, Xiaofang Xie*, Cheng Peng*. Chemistry, pharmacokinetics, pharmacological activities, and toxicity of Quercitrin. Phytother Res, 2022, 36(4):1545-1575.
9. Junyuan Qin, Junren Chen, Fu Peng*, Chen Sun, Yu Lei, Guangru Chen, Gangming Li, Yanpeng Yin, Ziwei Lin, Liujun Wu, Jing Li, Wenxiu Liu, Cheng Peng*, Xiaofang Xie*. Pharmacological activities and pharmacokinetics of liquiritin: A review. J Ethnopharmacol. 2022, 293: 115257.doi: 10.1016/j.jep.2022.115257
10. Wen-Qing Li, Jing Li, Wen-Xiu Liu, Liu-Jun Wu, Jun-Yuan Qin, Zi-Wei Lin, Xin-Yu Liu, Shi-Yan Luo,Qing-Hua Wu*, Xiao-Fang Xie*, Cheng Peng*. Isorhamnetin: A Novel Natural Product Beneficial for Cardiovascular Disease. Curr Pharm Des., 2022, 28(13): 2569-2582. doi: 10.2174/1381612828666220829113132.
11. 覃俊媛，孫晨，彭成，謝曉芳*.趕黃草水煎液對金黃色葡萄球菌和耐甲氧西林金黃色葡萄球菌生物膜形成的影響.中國抗生素雜志，2023，48（1）：54-61.
12. 張慧瓊，李剛敏，陳俊仁，謝曉芳*，熊亮，彭成*.西洋參總皂苷聯(lián)合順鉑對Luc-A549肺癌小鼠瘤體生長的影響.中藥藥理與臨床，2021，37（3）：50-55.
13. 李剛敏，彭成，許欣，李靜，謝曉芳*.基于大鼠離體心臟的附子組分強心作用初探.時珍國醫(yī)國藥，2021，32（2）：265-268.
14. 熊秋韻，張慧瓊，謝曉芳*，劉怡，熊亮，鄧青秀，彭成*.附子不同炮制品對風(fēng)濕寒痹類風(fēng)濕性關(guān)節(jié)炎大鼠的急性毒性試驗研究.中藥藥理與臨床，2020，36（2）：149-158.
15. 余蕾，謝曉芳，彭芙，謝君，李夢婷，彭成*. 趕黃草總黃酮對活化的肝星狀細(xì)胞TGF-β1/Smads信號通路的影響.天然產(chǎn)物研究與開發(fā)，2020，32：1118-1123.