劉菲
一、個(gè)人簡介
劉菲，博士，博士后，副教授，畢業(yè)于清華大學(xué)醫(yī)學(xué)部&北京協(xié)和醫(yī)學(xué)院藥物研究所，世界中醫(yī)藥學(xué)會(huì)聯(lián)合會(huì)道地藥材多維評(píng)價(jià)專業(yè)委員會(huì)會(huì)員、中華中醫(yī)藥協(xié)會(huì)會(huì)員。長期從事中藥藥效物質(zhì)基礎(chǔ)的相關(guān)研究，先后對(duì)藤石松、馬尾杉、粗糙馬尾杉、龍骨馬尾杉、鹿角杜鵑以及姜黃與莪術(shù)中的活性成分進(jìn)行了系統(tǒng)研究，分離獲得單體成分400余個(gè)，其中新成分100余個(gè)，包含5個(gè)新穎骨架類結(jié)構(gòu)。主持國家自然科學(xué)基金、四川省自然科學(xué)基金、博士后基金面上項(xiàng)目、校基金等各級(jí)課題5項(xiàng)。課題組探索發(fā)現(xiàn)姜黃和莪術(shù)活血功效差異與其所含的倍半萜有關(guān)，并發(fā)現(xiàn)姜黃沒藥烷型倍半萜類成分具有顯著的舒張血管作用，其作用機(jī)制與調(diào)控PI3K/Akt/eNOS通路有關(guān)，為心腦血管疾病新藥開發(fā)提供了苗頭化合物。目前，以第一作者或通訊作者發(fā)表SCI論文19篇，包括1區(qū)top期刊Organic Letters和2區(qū)期刊Biomedicine & Pharmacotherapy、Bioorganic Chemistry、Journal of Natural Products等，且在Tetrahedron中發(fā)表論文被選為封面文章。此外，以通訊作者發(fā)表中文核心期刊論文10余篇，申請(qǐng)專利2項(xiàng)。
二、代表性成果（可含承擔(dān)項(xiàng)目、發(fā)表論文、論著、獲獎(jiǎng)等）
?主持科研項(xiàng)目情況：
（1）四川省自然科學(xué)基金青年科學(xué)基金項(xiàng)目，2023NSFSC1773，基于鉀離子通道的莪術(shù)倍半萜舒張血管作用研究，2023/01-2024/12，10萬元，在研，主持
（2）成都中醫(yī)藥大學(xué)“杏林學(xué)者”學(xué)科人才科研提升計(jì)劃，QJRC2021008，蓬莪術(shù)倍半萜化學(xué)成分及其活血功效研究，2021/10-2024/10，18萬元，在研，主持
（3）國家自然科學(xué)基金青年科學(xué)基金項(xiàng)目，81903777，基于倍半萜“異型異效”研究姜黃和莪術(shù)活血功效差異的物質(zhì)基礎(chǔ)，2020/01-2022/12，21萬元，已結(jié)題，主持
（4）中國博士后科學(xué)基金面上項(xiàng)目，2019M653362，活血類藥姜黃和破血類藥莪術(shù)功效差異的物質(zhì)基礎(chǔ)研究，2020/01-2021/05，8萬元，已結(jié)題，主持
（5）成都中醫(yī)藥大學(xué)“杏林學(xué)者”學(xué)科人才科研提升計(jì)劃，BSH2018009，蓬莪術(shù)抗腫瘤活性成分研究，2018/07-2020/06，6萬元，已結(jié)題，主持
?代表性論文：
(1) Jin-Feng Chen#, Fei Liu#, Ming-Ming Qiao, Hong-Zhen Shu, Xiao-Cui Li, Cheng Peng*, Liang Xiong*, Vasorelaxant effect of curcubisabolanin A isolated from Curcuma longa through the PI3K/Akt/eNOS signaling pathway, Journal of Ethnopharmacology, 2022, 294: 115332.
(2) Juan Liu, Ming-Ming Qiao, Cheng Peng, Hong-Zhen Shu, Chun-Wang Meng, Fei Liu*, Liang Xiong*, Curcumanes E and F, two rare sesquiterpenoids with a dicyclo[3.3.1]nonane moiety, from Curcuma longa and their vasorelaxant activities, Frontiers in Chemistry, 2022, 10: 995950.
(3) Hong-Zhen Shu, Cheng Peng, Lan Bu, Li Guo, Fei Liu*, Liang Xiong*, Bisabolane-type sesquiterpenoids: Structural diversity and biological activity, Phytochemistry, 2021, 192: 112927.
(4) Fei Liu#, Jin-Feng Chen#, Ming-Ming Qiao, Hao-Yu Zhao, Qin-Mei Zhou, Li Guo, Cheng Peng*, Liang Xiong*, Seven pairs of new enantiomeric sesquiterpenoids from Curcuma phaeocaulis, Bioorganic Chemistry, 2020, 99: 103820.
(5) Fei Zhou#, Fei Liu#, Juan Liu, Yu-Lin He, Qin-Mei Zhou, Li Guo, Cheng Peng*, Liang Xiong*, Stachydrine promotes angiogenesis by regulating the VEGFR2/MEK/ERK and mitochondrial-mediated apoptosis signaling pathways in human umbilical vein endothelial cells, Biomedicine & Pharmacotherapy, 2020, 131: 110724.
(6) Ming-Ming Qiao#, Fei Liu#, Yu Liu, Li Guo, Qin-Mei Zhou, Cheng Peng*, Liang Xiong*, Curcumane C and (±)-curcumane D, an unusual seco-cadinane sesquiterpenoid and a pair of unusual nor-bisabolane enantiomers with significant vasorelaxant activity from Curcuma longa, Bioorganic Chemistry, 2019, 92: 103275.
(7) Fei Liu#, Jin-Feng Chen#, Yue Wang, Li Guo, Qin-Mei Zhou, Cheng Peng*, Liang Xiong*, Cytotoxicity of lanostane-type triterpenoids and ergosteroids isolated from Omphalia lapidescens on MDA-MB-231 and HGC-27 cells, Biomedicine & Pharmacotherapy, 2019, 118: 109273.
(8) Yu Liu#, Fei Liu#, Ming-Ming Qiao, Li Guo, Ming-Hua Chen, Cheng Peng*, Liang Xiong*, Curcumanes A and B, Two Bicyclic Sesquiterpenoids with Significant Vasorelaxant Activity from Curcuma longa, Organic Letters, 2019, 21(4): 1197-1201.
(9) Fei Liu#, Ya-Nan Wang#, Yong Li, Shuang-Gang Ma, Jing Qu, Yun-Bao Liu, Chang-Shan Niu, Zhong-Hai Tang, Yu-Huan Li, Li Li, Shi-Shan Yu*, Triterpenoids from the twigs and leaves of Rhododendron latoucheae by HPLC?MS?SPE?NMR, Tetrahedron, 2019, 75(2): 296-307.
(10) Fei Liu#, Ya-Nan Wang#, Yong Li, Shuang-Gang Ma, Jing Qu, Yun-Bao Liu, Chang-Shan Niu, Zhong-Hai Tang, Yu-Huan Li, Li Li, Shi-Shan Yu*, Minor Nortriterpenoids from the Twigs and Leaves of Rhododendron latoucheae, Journal of Natural Products, 2018, 81(8): 1721-1733.