王棟
一、個(gè)人簡介
博士，二級(jí)教授，博士生導(dǎo)師。四川省高層次引進(jìn)人才“千人計(jì)劃”學(xué)者，四川省學(xué)術(shù)和技術(shù)帶頭人。清華大學(xué)畢業(yè)獲得生物學(xué)博士學(xué)位，美國加州大學(xué)圣地亞哥分校進(jìn)行博士后研究工作。曾任清華大學(xué)醫(yī)學(xué)院研究員，博士生導(dǎo)師。
研究方向?yàn)橹嗅t(yī)藥分子腫瘤學(xué)，主要關(guān)注中西醫(yī)結(jié)合抗腫瘤的分子機(jī)制及藥物發(fā)現(xiàn)。相關(guān)研究工作以通訊作者或第一作者在Nature、Nature Structural & Molecular Biology、Science Advances、Cell Research、Nucleic Acids Research等國際知名刊物發(fā)表，其中2篇入選全球top 1%高被引論文，單篇最高引用次數(shù)>900。申請(qǐng)美國和中國專利18項(xiàng)，授權(quán)11項(xiàng)，轉(zhuǎn)化1項(xiàng)。主持教育部生物治療協(xié)同創(chuàng)新中心、自然科學(xué)基金委（3項(xiàng)）、北京市首都健康培育項(xiàng)目、四川省天府英才工程等多個(gè)項(xiàng)目?，F(xiàn)任中國醫(yī)藥教育協(xié)會(huì)健康管理專委會(huì)副主任委員，中國抗癌協(xié)會(huì)腫瘤轉(zhuǎn)移專業(yè)委員會(huì)委員，BMC Cancer等3個(gè)國際SCI刊物編委。
二、代表性成果
1. Yifei Dai, Weijie Qiang, Yu Gui, Xue Tan, Tianli Pei, Kequan Lin, Siwei Cai, Liang Sun, Guochen Ning, Jianxun Wang, Hongyan Guo, Yimin Sun, Jing Cheng, Lan Xie*, Xun Lan*, Dong Wang*. A large-scale transcriptional study reveals inhibition of COVID-19 related cytokine storm by traditional Chinese medicines. Science Bulletin, 2021, 66(9):884-888. （影響因子20.577）
2. Huili Wang，Kequan Lin, Lin Zhu, Shaojun Zhang, Le Li, Yilie Liao, Baichao Zhang, Ming Yang, Xinde Liu, Lu Li, Shasha Li, Liuqing Yang, Haiyan Wang, Qianyu Wang, Haitao Li, Suneng Fu, Xiaorong Zhang, Peng Jiang, Qiangfeng Cliff Zhang, Jing Cheng*, Dong Wang*. Oncogenic lncRNA LINC00973 promotes warburg effect by enhancing LDHA enzyme activity. Science Bulletin, 2021, 66(13):1330-1334 （影響因子20.577）
3. Haiyan Wang, Shasha Li, Qianyu Wang, Zhenshuo Jin, Wei Shao, Yan Gao, Lu Li, Kequan Lin, Lin Zhu, Huili Wang, Xuebin Liao, Dong Wang*. Tumor immunological phenotype signature-based high-throughput screening for the discovery of combination immunotherapy compounds. Science Advances. 7, eabd7851, 2021 （影響因子14.957）
4. Shuaishuai Teng, Yang Eric Li, Ming Yang, Rui Qi, Yiming Huang, Qianyu Wang, Yanmei Zhang, Shanwen Chen, Shasha Li, Kequan Lin, Yang Cao, Qunsheng Ji, Qingyang Gu, Yujing Cheng, Zai Chang, Wei Guo, Pengyuan Wang, Ivan Garcia-Bassets, Zhi John Lu*, Dong Wang*. Tissue-Specific Transcription Reprogramming Promotes Liver Metastasis of Colorectal Cancer. Cell Research, 2020, 30 :34-49 （影響因子46.297）
5. Kequan Lin, Lu Li, Yifei Dai, Huili Wang, Shuaishuai Teng, Xilinqiqige Bao, Zhi John Lu*, Dong Wang*. A comprehensive evaluation of connectivity methods for L1000 data. Briefings in Bioinformatics, 2020, 21: 2194–2205（影響因子13.994）
6. Wei Shao, Shasha Li, Lu Li, Kequan Lin, Xinhong Liu, Haiyan Wang, Huili Wang and Dong Wang*. Chemical genomics reveals inhibition of breast cancer lung metastasis by Ponatinib via c-Jun. Protein & Cell, 2019, 10(3):161-177.（影響因子15.328）
7. Shasha Li, Shuaishuai Teng, Junquan Xu, Guannan Su, Yu Zhang, Jianqing Zhao, Suwei Zhang, Haiyan Wang, Wenyan Qin, Zhi John Lu, Yong Guo, Qianyong Zhu*, Dong Wang*. Microarray is an efficient tool for circRNA profiling. Briefings in Bioinformatics, 2019, 20 :1420-1433. （影響因子13.994）
8. Dong Wang#, Ivan Garcia-Bassets#, Chris Benner#, Wenbo Li, Xue Su, Yiming Zhou,Jinsong Qiu, Wen Liu, Minna U. Kaikkonen, Kenneth A. Ohgi, Christopher K. Glass, Michael G. Rosenfeld and Xiang-Dong Fu. Reprogramming transcription via distinct classes of enhancers functionally defined by eRNA. Nature, 2011, 474:390–394. (#These authors contributed equally to this work). （影響因子69.504）