方玉宇
一、個(gè)人簡(jiǎn)介
方玉宇，有機(jī)化學(xué)博士，中藥學(xué)博士后，成都中醫(yī)藥大學(xué)藥學(xué)院/現(xiàn)代中藥產(chǎn)業(yè)學(xué)院副教授、碩士研究生導(dǎo)師，比利時(shí)魯汶大學(xué)（KU Leuven）訪問(wèn)學(xué)者，四川省海外高層次留學(xué)人才，中藥化學(xué)系教工黨支部書記，曾掛任成都市溫江區(qū)科技局副局長(zhǎng)，主要從事基于中藥藥效物質(zhì)基礎(chǔ)篩選新方法研究、天然藥物活性成分的分子探針并用于疾病的“診療一體化”及作用靶點(diǎn)發(fā)現(xiàn)研究和超分子識(shí)別與自組裝研究。先后主持國(guó)家自然科學(xué)基金、中國(guó)博士后科學(xué)基金面上資助、四川省自然科學(xué)基金面上項(xiàng)目、四川省科技廳應(yīng)用基礎(chǔ)研究計(jì)劃等各級(jí)各類科研項(xiàng)目14項(xiàng)，以第一作者或通訊作者在Coordin. Chem. Rev., Biosen. Bioelectron., J. Hazard. Mater., Sensor. Actuat. B -Chem., Food Chem., Trends Environ. Anal. Chem., Anal. Chim. Acta, Bioorg. Chem., Microchem. J., Chem. Commun., Spectrochim. Acta A等國(guó)際知名期刊共發(fā)表論文SCI論文30余篇，參編全國(guó)高等中醫(yī)藥院校中藥學(xué)類專業(yè)雙語(yǔ)規(guī)劃教材《有機(jī)化學(xué)》，先后獲得四川省科技進(jìn)步二等獎(jiǎng)、第十一屆全國(guó)中醫(yī)藥院?！皟?yōu)秀青年”、成都中醫(yī)藥大學(xué)“優(yōu)秀黨務(wù)工作者”、成都中醫(yī)藥大學(xué)第二屆“本科課堂教學(xué)質(zhì)量二等獎(jiǎng)”等榮譽(yù)或獎(jiǎng)勵(lì)。
二、代表性科研論文：
(1) Jia Li, Xin Kang, Nianjia Liu, Ao Zhang, Longxuan Li, Xuan Zhao, Yuzhi Li, Houcheng Zhou, Yun Deng, Cheng Peng*, Zhixing Cao*, Yuyu Fang*. A robust H2O2-responsive AIEgen with multiple-task performance: Achieving food analysis, visualization of dual organelles and diagnosis of liver injury. Biosen. Bioelectron. 2025, 276, 117276. (中科院一區(qū)top期刊，IF = 10.7)
(2) Yuting Su?, Longxuan Li?, Peini Xiang, Nianjia Liu, Jianjun Huang*, Houcheng Zhou, Yun Deng, Cheng Peng, Zhixing Cao*, Yuyu Fang*. The first ER-targeting flavone-based fluorescent probe for Cys: applications in real-time tracking in an epilepsy model and food analysis. Spectrochim. Acta A 2025, 324, 124975. (中科院二區(qū)期刊，IF = 4.3)
(3) Longxuan Li, Jia Li, Xin Liu, Xuan Zhao, Ao Zhang, Yun Deng, Cheng Peng, Zhixing Cao*, Wim Dehaen*, Yuyu Fang*. Shortening the early diagnostic window of Hg2+-induced liver injury with a H2O2-activated fluorescence/afterglow imaging assay. J. Hazard. Mater. 2024, 480, 136059. (中科院一區(qū)top期刊，IF = 12.2)
(4) Xuan Zhao, Xiaoxue Hu, Longxuan Li, Yuanping Liu, Boshuang Song, Yuzhi Li*, Zhixing Cao, Houcheng Zhou, Cheng Peng, Yun Deng*, Yuyu Fang*. Simultaneous visualization of lipid droplets and tracking of the endogenous hypochlorous acid in psoriatic mice models with a novel fluorescent probe in a wash-free fashion. Bioorg. Chem. 2024, 153, 107967. (中科院二區(qū)top期刊，IF = 4.5)
(5) Dongbin Zheng?, Yi Zuo?, Longxuan Li, Arlene McDowell, Yuening Cao, Xiaoping Ye*, Houcheng Zhou, Cheng Peng, Yun Deng*, Jun Lu*, Yuyu Fang*. Natural harmaline acts as novel fluorescent probe for hypochlorous acid and promising therapeutic candidate for rheumatoid arthritis. J. Photoch. Photobio. B 2024, 258, 112995. (中科院二區(qū)，IF = 3.9)
(6) Longxuan Li, Xuan Zhao, Yin Tian, Jia Li, Zhiqiang Yang, Xin Liu, Yuzhi Li*, Zhixing Cao, Cheng Peng, Yun Deng*, Wim Dehaen*, Yuyu Fang*. A novel fluorescent probe with tailored properties for ozone: applications in on-site environmental monitoring and real-time bioimaging in Parkinson’s disease models. Sensor. Actuat. B -Chem. 2024, 418, 136248. (中科院一區(qū)top期刊，IF = 8.0)
(7) Jia Li, Zhiqiang Yang, Wenya Yang, Xuan Zhao, Longxuan Li, Zhixing Cao, Houcheng Zhou, Renlin Zheng, Yun Deng, Cheng Peng*, Yuzhi Li*, Yuyu Fang*. A novel AIE-based mitochondria-targeting fluorescent probe for monitoring of the fluctuation of endogenous hypochlorous acid in ferroptosis models. Anal. Bioanal. Chem. 2024, 416, 4873-4885. (中科院二區(qū)，IF = 3.8)
(8) Zhiqiang Yang, Xin Kang, Jia Li, Longxuan Li, Xiaoping Ye, Xiaoya Liu*, Kun Chen, Yun Deng, Cheng Peng, Bo Ren*, Zhixing Cao*, Yuyu Fang*. A novel LD-targeting cysteine-activated fluorescent probe for diagnosis of APAP-induced liver injury and its application in food analysis. Food Chem. 2024, 456, 140064. (中科院一區(qū)top期刊，IF = 8.5)
(9) Yuyu Fang?*, Dongbin Zheng?, Tingrui Zhang, Zhixing Cao*, Houcheng Zhou, Yun Deng, Cheng Peng*. A rationally designed fluorescent probe for sulfur dioxide and its derivatives: applications in food analysis and bioimaging. Anal. Bioanal. Chem. 2024, 416, 533-543. (中科院二區(qū)期刊，IF = 3.8)
(10) Zhiqiang Yang, Jia Li, Sining Li, Jingxi Zhou, Zhixing Cao*, Longxuan Li, Dongbin Zheng, Xuan Zhao, Wei Wang, Yun Deng*, Yuyu Fang*. Real-time monitoring of endogenous cysteine in LPS-induced oxidative stress process with a novel lysosome-targeted fluorescent probe. Anal. Chim. Acta 2023, 1279, 341819. (中科院二區(qū)top期刊，IF = 5.7)
(11) Jianjun Huang, Dongbin Zheng, Yuyu Fang*, Wim Dehaen*. Design and synthesis of a BOAHY-derived tracker for fluorescent labeling of mitochondria. Spectrochim. Acta A 2023, 303, 123201. (中科院二區(qū)期刊，IF = 4.3)
(12) Dongbin Zheng, Jianjun Huang, Yuyu Fang*, Yun Deng, Cheng Peng*, Wim Dehaen*. Fluorescent probes for ozone-specific recognition: An historical overview and future perspectives. Trends Environ. Anal. Chem. 2023, 38, e00201. (中科院二區(qū)top期刊，IF = 11.1)
(13) Ying Huang?, Dongbin Zheng?, Jing Bai, Wei Wang*, Zhiqiang Yang, Yin Tian*, Yuyu Fang*. The first chrysin-based receptor for anions recognition: Experimental investigations, DFT studies and its in vitro antitumor activity. J. Mol. Struct. 2023, 1286, 135637. (中科院二區(qū)期刊，IF = 4.0)
(14) Dongbin Zheng, Tingrui Zhang, Ying Huang, Hanlin Chen, Yuzhi Li*, Zhixing Cao, Yun Deng, Yuyu Fang*, Cheng Peng*. Phenoxazine-conjugated-benzoeindolium as a novel mitochondria-targeted fluorescent probe for turn-on detection of sulfur dioxide and its derivatives in vivo. Microchem. J. 2022, 175, 107192. (中科院二區(qū)top期刊，IF = 4.9)
(15) Miao Wang, Ruoqi Zhang, Wim Dehaen, Yuyu Fang*, Shan Qian, Yali Ren, Fang Cheng, Yuying Guo, Chuanjie Guo, Yuzhi Li, Yun Deng, Zhixing Cao*, Cheng Peng*. Specific recognition, intracellular assay and detoxification of fluorescent curcumin derivative for copper ions. J. Hazard. Mater. 2021, 420, 126490. (中科院一區(qū)top期刊，IF = 12.2)
(16) Yuyu Fang, Wim Dehaen*. Small-molecule-based fluorescent probes for f-block metal ions: A new frontier in chemosensors, Coordin. Chem. Rev. 2021, 427, 213524. (中科院一區(qū)top期刊，IF = 20.3)
(17) Yuyu Fang, Yun Deng*, Wim Dehaen*. Tailoring pillararene-based receptors for specific metal ion binding: From recognition to supramolecular assembly. Coordin. Chem. Rev. 2020, 415, 213313. (中科院一區(qū)top期刊，IF = 20.3)