李銳
一、個(gè)人簡(jiǎn)介
李銳，教授，2011年畢業(yè)于北京大學(xué)醫(yī)學(xué)部“天然藥物與仿生藥物國家重點(diǎn)實(shí)驗(yàn)室”，獲得博士學(xué)位，師從北京大學(xué)藥學(xué)院果德安教授、葉敏教授。
海外經(jīng)歷：2013年赴意大利比薩大學(xué)（University of Pisa）參與中歐Hyanji科研合作項(xiàng)目, 擔(dān)任Experienced Researcher。
所在學(xué)院：成都中醫(yī)藥大學(xué)藥學(xué)院中藥化學(xué)系中藥分析教研室；
人才項(xiàng)目：四川省杰出青年科技人才、成都市高新區(qū)“金熊貓”高層次人才、四川省學(xué)術(shù)和技術(shù)帶頭人后備人選；
學(xué)術(shù)兼職：擔(dān)任國家自然科學(xué)基金函評(píng)專家、擔(dān)任Journal of Functional Foods、Food&Function、Current Pharmaceutical Analysis、Pharmaceutical Biology、Current Pharmaceutical Analysis、PLOS ONE、Journal of Pharmacy and Pharmacology、American Journal of Chinese Medicine、Journal of Renewable Materials、Human Cell等期刊審稿人；
研究方向：①.活性天然產(chǎn)物的化學(xué)分析、體內(nèi)過程及產(chǎn)業(yè)化開發(fā)；②.中藥“食藥同源”功能因子的遞送增效技術(shù)。
研究專長(zhǎng)：①.姜黃的系統(tǒng)研究及產(chǎn)業(yè)化開發(fā)；②.姜黃素的遞送增效技術(shù)開發(fā)。
二、代表性成果（可含承擔(dān)項(xiàng)目、發(fā)表論文、論著、獲獎(jiǎng)等）
承擔(dān)項(xiàng)目：
主持國家自然科學(xué)基金面上項(xiàng)目、青年基金2項(xiàng)(82073994、81302742, 國家自然科學(xué)基金委員會(huì))、四川省杰出青年科技人才基金1項(xiàng)(2020JDJQ0049, 四川省科技廳)、教育部春暉計(jì)劃2項(xiàng)(1383127、13205638，中國教育部)、 中國博士后科學(xué)基金會(huì)面上項(xiàng)目1項(xiàng)(2012M511843，中國博士后科學(xué)基金會(huì))、四川省教育廳重點(diǎn)項(xiàng)目1項(xiàng)(11ZA005，四川省教育廳)等10余個(gè)縱向科研項(xiàng)目；
代表論文：
(1) Qiongdan Hu, Ruyu Ma, Xinxing Tang, Rui Long, Qi Wang, Chaomei Fu*, Rui Li *, Hang Xiao*. Self-assembled nanoparticles of curcuminoids and soluble dietary fibers: characterization and mechanism. LWT-Food Science and Technology, IF=6.06, 2023, (173): 114375.
(2) Qiongdan Hu1, Wan Liao1, Zhen Zhang, Sanjun Shi, Shuguang Hou, Ningping Ji, Xinjie Zhang, Qian Zhang, Yangyang Liao, Linghui Li, Zongping Zhu, Yi Chen, Jiao Chen, Fangkun Yu, Qingsong Yang , Hongtao Xiao , Chaomei Fu*, Heping Cao , Hang Xiao* and Rui Li*. The hepatoprotective effects of plant-based foods based on the “gut–liver axis”: a prospective review. Critical Reviews in Food Science and Nutrition, IF=11.21, Published online: 25 Apr 2022
(3) Linghui Li#, Wan liao#, Fangkun Yu, Liwei Tan, Zhangcai Li, Qiongdan Hu, Xinjie Zhang, Yangyang Liao, Shuguang Hou*, Rui Li*, Optimization of curcumin-lactoferrin nanoparticles prescription process based on Box-Behnken design-response surface method and in vitro evaluation, Chinese Traditional and Herbal Drugs, 2022,53(19):5980-5990.
(4) Zongping Zhu#, Jiao Chen#, Yi Chen, Yuntong Ma, Qingsong Yang, Yunqiu Fan, Chaomei Fu, Boonjai Limsila, Rui Li*, Wan Liao*. Extraction, structural characterization and antioxidant activity of turmeric polysaccharides. LWT-Food Science and Technology, IF=6.06, 2022, (154): 112805.
(5) Yi Chen#, Wan Liao#, Zongping Zhu, Jiao Chen, Qingsong Yang, Yongfeng Zheng, Xinjie Zhang, Boonjai Limsila, Meigui Lu, Shu Fu* and Rui Li*. Essential oil from the raw and vinegar-processed Rhizoma Curcumae ameliorate CCl4-induced liver fibrosis:integrating network pharmacology and molecular mechanism evaluation. Food & Function, IF=6.317, 2021,12(9): 4199-4220.
(6) Zongping Zhu#, Jisen Wang#, Wan liao*, Jiao Chen, Yi Chen, Qingsong Yang, Rui Li*, Yuntong Ma, Chaomei Fu, Effect and mechanism of Curcuma longa anti-angiogenesis based on model biology zebrafish, Chinese Traditional and Herbal Drugs, 2021,52(11):3257-3268.
(7) Wan Liao#, Qian Zhang#, Liangkun Sun, Feng Dong, Fang Liu, Yuxin He, Ling Li, Shuguang Hou, Rui Li*, Hongtao Xiao*, Qualitative and quantitative analysis of trace element of terpenoid conjugated curcuminoid and curcuminoids in herbal medicine derived from different Curcuma species, Chinese Traditional and Herbal Drugs, 2020,51(4): 1076-1081.
(8) Rui Li*, Fang Liu, Xiao Yang, Lian-qi Chen, Fei Wang, Guo-lin Zhang, Qian Zhang, Liang Zhang, Yu-xin He, Yu-feng Li, Peng Lai, Xiang-gui Chen, Min Ye, Hong-tao Xiao and Hang Xiao*. Analysis of bisabolocurcumin ether (a terpene-conjugated curcuminoid) and three curcuminoids in Curcuma species from different regions by UPLC-ESI MS/MS and their in vitro anti-inflammatory activities. Journal of Functional Foods. 2019, 52(1): 186-195.
(9) Fang Liu, Qian Zhang, Rui Li*, Hongtao Xiao*, Tingting Kuang, Xueqian Ouyang, Hengfu Yin, Effects of surfactants on water solubility and anti-hepatic fibrosis of curcuminoids. Chinese Traditional and Herbal Drugs, 2018, (8):1809-1815.
(10) Rui Li, Qi Wang, Jing-Ran Fan, Jun-Bin He, Xue Qiao, Cheng Xiang, De-An Guo, Min Ye*. Metabolites Identification of Curcumin, Demethoxycurcumin and Bisdemethoxycurcuminin Rats After Oral Administration of NanoparticleFormulations by Liquid Chromatography Coupled with Mass Spectrometry. World Journal of Traditional Chinese Medicine. 2016; 2(4): 29-37)
(11) Rui Li, Kun Jia, Qiang Fu, Jingwen Luo, Li Deng, LC-MS guided discovery, structural elucidation of a new curcuminoids, and its cytotoxicity, Chinese Traditional and Herbal Drugs, 2016,47(14):2418-2423.
(12). Wan Liao, Yan Xiong Gan, Si Lei Zhao, Ni Ni Luo, Nuriza Rahmadini, Francesca Giannotta, Chao Mei Fu*, Rui Li*, Ji Sen Wang. Comparative analysis of trace elements contained in Rhizoma Curcumae from different origins and their vinegar products by ICP-MS. Analytical Methods, 2014, 6(20): 8187-8192.
(13). Rui Li, Cheng Xiang, Min Ye*, Hui-Fang Li, Xing Zhang, De-An Guo*. Qualitative and quantitative analysis of curcuminoids in herbal medicines derived from Curcuma species. Food Chemistry, 2011, 126(4): 1890-1895.
(14). Rui Li#, Xue Qiao#, Qingyan Li, Rong He, Min Ye*, Cheng Xiang, Xionghao Lin, Dean Guo*. Metabolic and Pharmacokinetic Studies of Curcumin, Demethoxycurcumin, and Bisdemethoxycurcumin in Rat Tumor after Intragastric Administration of Nanoparticle Formulations by Liquid Chromatography Coupled with tandem Mass Spectrometry. Journal of Chromatography B, 2011, 879(26): 2751-2758.
(15). Rui Li, Cheng Xiang, Xing Zhang, De-An Guo, Min Ye*. Chemical Analysis of the Chinese Herbal Medicine Turmeric (Curcuma longa L.). Current Pharmaceutical Analysis, 2010, 6(4): 256-268.
論著：
本草專著《桂本草》，特約編輯，國家出版基金項(xiàng)目，北京科學(xué)技術(shù)出版社，2014年12月出版。
授權(quán)專利：
(1). 載姜黃素的聚乳酸生物支架及其制備方法；(ZL201510852174.5);
(2). 姜萜環(huán)素的制備方法和抗肝纖維化應(yīng)用; (ZL201610605923.9);
(3). 一種滋陰潤(rùn)肺，抗疲勞的功能性保健飲料及其制備方法；(ZL201710536413.5)；