王繼剛
教授，博士生導(dǎo)師，“珠江學(xué)者”講座教授，“天府學(xué)者”特聘專家，國家中醫(yī)藥傳承創(chuàng)新團隊首席科學(xué)家，中國中醫(yī)科學(xué)院青蒿素研究中心副主任,首席研究員。主要研究青蒿素抗瘧、抗癌的機制以及其他藥物及天然產(chǎn)物的藥物靶標與作用機理。課題組結(jié)合化學(xué)生物學(xué)、蛋白質(zhì)組學(xué)、代謝組學(xué)、分子生物學(xué)以及單細胞測序等相關(guān)交叉領(lǐng)域的研究方法、圍繞藥物的作用靶點及其作用機制展開系統(tǒng)研究。近年來在包括青蒿素在內(nèi)的中藥及天然產(chǎn)物的靶標、作用機理和抗藥研究及細胞自噬藥物篩選平臺建立等方面取得了一系列研究進展與突破，近年來以通訊/第一作者在New England Journal of Medicine、 Lancet、Lancet Infectious Disease, Nature Communications、Nature Protocols、JACS、Angew. Chem. Intl. Ed.、ACS Central Science、ACS Nano、Autophagy、Trends in Pharmacological Sciences、Pharmacology & Therapeutics、Journal of Extracellular Vesicles、 Medicinal Research Reviews等國際高水平刊物上發(fā)表論文140余篇（影響因子>2500），其中影響因子大于10的70余篇，撰寫Methods Enzymol.書籍章節(jié)3篇。同時兼職多種國際權(quán)威刊物的編委或?qū)徃迦?。近年來主持國家中醫(yī)藥傳承創(chuàng)新團隊項目，國自然面上，科技部重大專項子項目，科技部新藥創(chuàng)制專項子項目等國家、省市級課題20余項。申請專利20余項。
代表性成果：
1.Xia P#, Yuan HT#, Tian M#, Zhong TY#, Hou R, Xu XL, Ma JB, Wang HF, Li ZF, Huang DF, Qu CM, Dai LY, Xu CC, Yang CB, Jiang HB, He YQ, Rückert F, Li ZJ*, Yuan YF*, Wang JG*. (2022) Surface-Engineered Extracellular Vesicles with CDH17 Nanobodies to Efficiently Deliver Imaging Probe and Chemo-Photothermal Drugs for Gastric Cancer Theragnostic. Advanced Functional Materials. 2209393. *(Corresponding author) (IF:19.924 )
2.Wang JG, Xu CC, Wong YK, He YK, Adegnika AA, Kremsner PG, Agnandji ST, Sall AA, Liang Z, Qiu C, Liao FL, Jiang TL. Krishna S, Tu Youyou*. (2020) Preparedness is essential for malaria-endemic regions during the COVID-19 outbreak. Lancet. 395(10230):1094-1096. (IF:202.731)
3.Wang JG*, Xu CC*, Liao FL, Jiang TL, Sanjeev K*, Tu Youyou. (2019) A Temporising Solution to "Artemisinin Resistance". New England Journal of Medicine. 380:2087-2089 (Corresponding author) (IF:176.079)
4.Luo P#, Liu DD#, Zhang Q#, Yang F#, Wong YK, Xia F, Zhang JZ, Chen JY, Tian Y, Yang CB, Dai LY*, Shen HM*, Wang JG*. (2022) Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1. Acta Pharmaceutica Sinica B. 12(5):2300-2314. *(Corresponding author) (IF: 14.903)
5.Zhang Q#, Xia F#, Luo P#, Chen JY, Zhang JZ, Liu DD , Zhu YP, Liu YQ, Gu LW, Tang H, Zheng LH, Li ZJ, Yang F, Dai LY, Xu CC. *Wang JG. (2022).Chemoproteomics reveals capsaicin ameliorated inflammation via targeting PKM2 mediated Warburg effect in sepsis. Cell Chemical Biology . 29, 1248–1259.*(Corresponding author). (IF:9.039)
6.Zhang W#, Xia SY#, Xiao W#, Song YL#, Tang L, Cao M, Yang J, Wang S, Li ZJ, Xu CC, Liu JQ*, Zhao SC*, Yang CB*, Wang JG*. (2022) A Single-Cell Transcriptomic Landscape of Mouse Testicular Aging. Journal of Advanced Research. DOI:10.1016/j.jare.2022.12.007. (*Corresponding author) (IF: 11.6)
7.Yuan HT#, Hong XP#, Ma H#, Fu CJ#, Guan YD, Huang W, Ma JB, Xia P, Cao M, Zheng LH, Xu XL, Xu CC, Liu DZ*, Li ZJ*, Geng QS*, Wang JG*. (2022) MXenes-Based Dual Functional Nanocomposite with Photothermal Nanozyme Catalytic Activity to Fight Bacterial Infections. ACS Materials Letters, DOI:10.1021/acsmaterialslett.2c00771 *(Corresponding author) (IF: 11.170).
8.?apc? A, Lorion MM, Wang H, Simon N, Leidenberger M, Silva MB, Moreira DR, Zhu YP, Meng YQ, Chen YJ, Lee YM, Friedrich O, Kappes B, Wang JG*, Ackermann L*. Tsogoeva S*. (2019) Artemisinin–(Iso)quinoline Hybrids by C?H Activation and Click Chemistry: Combating Multidrug‐Resistant Malaria. Angew. Chem. Int. Ed., 58(37):13066–13079. *(Corresponding author) (IF:16.823) (Cover story) Highlighted in Nature, Top Downloaded Paper.
9.Zhang JB#*, Sun X#, Wang LM#, Wong YK, Lee YM, Zhou C, Wu GQ, Zhao TW, Yang L, Lu LQ, Zhong JN, Huang DS*, Wang JG*. (2018). Artesunate-induced mitophagy alters cellular redox status. Redox biology, 19, 263-273. *(Corresponding author) (IF: 10.787)
10.Wang JG#*, Zhang CJ#, Chia WN, Loh CCY, Li ZJ, Lee YM, He YK, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang JB, Lu NC, Lim CT, Hua ZC, Liu B, Shen HM, Tan KSW*, Lin QS*. (2015) Haem-activated Promiscuous Targeting of Artemisinin in Plasmodium falciparum. Nature Communications, 6:10111. *(Corresponding author) (IF:17.694) (525cites)