敖慧
一、個(gè)人簡(jiǎn)介
敖慧，博士、教授、碩士生導(dǎo)師，中醫(yī)藥創(chuàng)新研究院；學(xué)術(shù)任職和兼職；中華中醫(yī)藥學(xué)會(huì)中成藥分會(huì)副秘書(shū)長(zhǎng)，主要從事中藥配伍理論及中藥品種、品質(zhì)與藥效研究；主持國(guó)家級(jí)課題1項(xiàng)，省部級(jí)3項(xiàng)，廳局級(jí)5項(xiàng)，主研“973”、國(guó)家自然基金等國(guó)家級(jí)、省部級(jí)課題8項(xiàng)。發(fā)表學(xué)術(shù)論文90篇，其中以第一作者或通訊作者發(fā)表SCI18篇（最高影響因子11.208，含高被引1篇），合計(jì)影響因子100，中文核心30篇，一般10篇；出版教材2部，專(zhuān)著10部，其中副主編3部，編委7部。
二、代表性成果內(nèi)容簡(jiǎn)介
1.人參白術(shù)配伍緩解化療相關(guān)性腹瀉的增效機(jī)制研究
采用了16SrDNA技術(shù)深入探討人參皂苷和白術(shù)揮發(fā)油配伍治療化療后腹瀉的增效機(jī)制。16S rDNA擴(kuò)增子測(cè)序的結(jié)果表明人參白術(shù)有效組分配伍后能夠有效抑制5-Fu對(duì)小鼠糞便中腸道菌群整體結(jié)構(gòu)的變化。在門(mén)水平上，5-Fu顯著性升高了Firmicutes的相對(duì)豐度，降低了Proteobacteria的相對(duì)豐度和Firmicutes/Bacteroidetes（F/B）。在屬水平，5-Fu明顯增加了與腹瀉有關(guān)的潛在致病菌Bacteroides、Ruminococcus、Anaerotruncus和Desulfovibrio的相對(duì)豐度。單用人參皂苷或白術(shù)揮發(fā)油不能逆轉(zhuǎn)5-Fu造成的上述腸道菌群結(jié)構(gòu)和門(mén)、屬豐度的變化。然而，配伍后能夠有效地調(diào)節(jié)腸道菌群不同門(mén)的豐度接近正常組，恢復(fù)F/B的比例，并能在屬的水平上顯著抑制5-Fu對(duì)上述潛在致病菌的促進(jìn)作用和單用AMO和PGS對(duì)Blautia、Parabacteroides和Lactobacillus豐度變化的副作用。該結(jié)果為揭示相須藥對(duì)的科學(xué)內(nèi)涵提供了依據(jù)。
2.陽(yáng)春砂仁和綠殼砂仁揮發(fā)油比較研究
本研究采用GC-MS和化學(xué)計(jì)量學(xué)比較研究了陽(yáng)春砂仁和綠殼砂仁揮發(fā)油化學(xué)成分。結(jié)果表明：順式橙花苷只存在于綠殼砂仁揮發(fā)油中。乙酸龍腦酯和樟腦分別被認(rèn)為是區(qū)分二者最重要的成分。此外，層次聚類(lèi)分析（HCA）和主成分分析（PCA）成功地區(qū)分了兩種揮發(fā)油的化學(xué)成分。此外，偏最小二乘判別分析（PLS-DA）顯示乙酸龍腦酯、α-卡地諾、芳樟醇、β-月桂烯、樟腦、D-檸檬烯、萜品烯和冰片等成分可作為鑒別兩者的潛在標(biāo)記物。綜上所述，本研究為鑒別兩種砂仁提供了一種科學(xué)的方法。
三、招生專(zhuān)業(yè)
| 代碼 | 二級(jí)學(xué)科 | 所屬學(xué)院 |
| 100800 | 中藥學(xué) | 藥學(xué)院 |
四、代表性成果
[1] Shengmao Li#, Yu Huang#, Lin Liu, Fan Zhang, Hui Ao*, Yingping Luo*. Mechanism of Magnolia Volatile Oil in the Treatment of Acute Pancreatitis Based on GC-MS, Network Pharmacology, and Molecular Docking [J]. Evidence-based complementary and alternative medicine : eCAM, 2023, 2023: 3503888.
[2] Yu Yang, Jiaojiao Wu, Jia Xia, Yan Wan, Jinfeng Xu, Li Zhang, Dong Liu, Lu Chen, Fei Tang, Hui Ao*, Cheng Peng*. Can aloin develop to medicines or healthcare products? [J]. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, 153: 113421.
[3] Yan Wan, Jia Xia, Jinfeng Xu, Lu Chen, Yu Yang, Jiaojiao Wu, Fei Tang, Hui Ao*, Cheng Peng*. Nuciferine, an active ingredient derived from lotus leaf, lights up the way for the potential treatment of obesity and obesity-related diseases [J]. Pharmacological research, 2022, 175: 106002.
[4] Yan Wan, Dong Liu, Jia Xia, Jinfeng Xu, Li Zhang, Yu Yang, Jiaojiao Wu, Hui Ao*. Ginsenoside CK, rather than Rb1, possesses potential chemopreventive activities in human gastric cancer via regulating PI3K/AKT/NF-κB signal pathway [J]. Frontiers in pharmacology, 2022, 13: 977539.
[5] Jiaojiao Wu, Yu Yang, Yan Wan, Jia Xia, Jinfeng Xu, Li Zhang, Dong Liu, Lu Chen, Fei Tang, Hui Ao*, Cheng Peng*. New insights into the role and mechanisms of ginsenoside Rg1 in the management of Alzheimer's disease [J]. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, 152: 113207.
[6] Jinfeng Xu, Jia Xia, Yan Wan, Yu Yang, Jiaojiao Wu, Cheng Peng*, Hui Ao*. Vasorelaxant Activities and its Underlying Mechanisms of Magnolia Volatile Oil on Rat Thoracic Aorta Based on Network Pharmacology [J]. Frontiers in pharmacology, 2022, 13: 812716.
[7] Jia Xia, Yan Wan, Jiaojiao Wu, Yu Yang, Jinfeng Xu, Li Zhang, Dong Liu, Lu Chen, Fei Tang, Hui Ao*, Cheng Peng*. Therapeutic potential of dietary flavonoid hyperoside against non-communicable diseases: targeting underlying properties of diseases [J]. Critical reviews in food science and nutrition, 2022, null: 1-31.
[8] Yan Wan, Jing Wang, Jinfeng Xu, Fei Tang, Lu Chen, Yuzhu Tan, Chaolong Rao, Hui Ao*, Cheng Peng*. Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects [J]. Journal of ginseng research, 2021, 45(6): 617-30.
[9] Jinfeng Xu, Yan Wan, Fei Tang, Lu Chen, Yu Yang, Jia Xia, Jiaojiao Wu, Hui Ao*, Cheng Peng*. Emerging Significance of Ginsenosides as Potentially Reversal Agents of Chemoresistance in Cancer Therapy [J]. Frontiers in pharmacology, 2021, 12: 720474.
[10] Fei Tang#, Yongming Yan#, Hongling Yan, Lixia Wang, Changjiang Hu, Hongliang Wang, Hui Ao*, Cheng Peng*, Yuzhu Tan*. Chuanxiongdiolides R4 and R5, phthalide dimers with a complex polycyclic skeleton from the aerial parts of Ligusticum chuanxiong and their vasodilator activity [J]. Bioorganic chemistry, 2021, 107: 104523.
[11] Fei Tang#, Hongling Yan#, Lixia Wang, Jinfeng Xu, Cheng Peng*, Hui Ao*, Yuzhu Tan*. Review of Natural Resources With Vasodilation: Traditional Medicinal Plants, Natural Products, and Their Mechanism and Clinical Efficacy [J]. Frontiers in pharmacology, 2021, 12: 627458.
[12] Hui Ao#; Wuwen Feng#; Cheng Peng*; Hydroxysafflor Yellow A: A Promising Therapeutic Agent for a Broad Spectrum of Diseases, Evidence-Based Complementary and Alternative Medicine, 2018, 8259280,1-17
[13] Wuwen Feng#; Hui Ao#; Shijun Yue; Cheng Peng(*), Systems pharmacology reveals the unique mechanism features of Shenzhu Capsule for treatment of ulcerative colitis in comparison with synthetic drugs, Scientific reports, 2018, 8,16160.
[14] Jing Wang#;Wuwen Feng#; Fei Tang; Hui Ao*; Cheng Peng*; Gut microbial transformation, a potential improving factor in the therapeutic activities of four groups of natural compounds isolated from herbal medicines, Fitoterapia, 2019,138,104293.
[15] Jing Wang#;Wuwen Feng#;Shiyang Zhang;Lu Chen;Yongcheng Sheng;Fei Tang;Junlin He;Xin Xu;Hui Ao*;Cheng Peng*;Ameliorative effect of Atractylodes macrocephala essential oil combined with Panax ginseng total saponins on 5-fluorouracil induced diarrhea is associated with gut microbial modulation, Journal of Ethnopharmacology,2019,238, 111887
[16] Jing Wang#; Wuwen Feng#; Shiyang Zhang; Lu Chen, Fei Tang; Yongcheng Sheng;Hui Ao*;Cheng Peng*; Gut microbial modulation in the treatment of chemotherapy-induced diarrhea with Shenzhu Capsule, BMC Complementary and Alternative Medicine, 2019, 19:126.
[17] Hui Ao, Jing Wang, Lu Chen*; Shengmao Li*; Chunmei Dai*; Comparison of Volatile Oil between the Fruits of Amomum villosum Lour. and Amomum villosum Lour. var. xanthioides T. L. Wu et Senjen Based on GC-MS and Chemometric Techniques, Molecules, 2019, 24, 1663
[18] 許金鳳,萬(wàn)彥,王晶,唐飛,敖慧*,彭成*.氣相色譜-質(zhì)譜聯(lián)用技術(shù)分析紫蘇葉、厚樸共煎煮前后揮發(fā)油成分的變化[J].中藥新藥與臨床藥理,2020,31(07):848-854.
[19] 張世洋,劉美辰,唐飛,王晶,敖慧*.人參、白術(shù)有效組分群對(duì)慢性萎縮性胃炎大鼠口腔、腸道菌群的影響[J].中成藥,2020,42(01):48-54.
[20] 唐飛,劉美辰,張世洋,王晶,盛永成,馮五文,孫家宜,敖慧*.廣藿香、厚樸配伍前后揮發(fā)油化學(xué)成分及抗菌活性對(duì)比研究[J].中藥新藥與臨床藥理,2019,30(04):478-483.
[21] 張世洋,劉美辰,唐飛,王晶,敖慧*.人參配伍白術(shù)前后皂苷成分及治療慢性萎縮性胃炎的活性比較[J].中藥藥理與臨床,2019,35(01):117-121.
[22] 黃雅彬,劉紅梅,方成鑫,庾洋,陳泓竹,張世洋,李生茂,敖慧*.不同品種川貝母生物堿鎮(zhèn)咳、抗炎作用比較[J].中藥新藥與臨床藥理,2018,29(01):19-22.
[23] 敖慧.從“同類(lèi)不可離”解析相須科學(xué)內(nèi)涵[J].中國(guó)中醫(yī)基礎(chǔ)醫(yī)學(xué)雜志,2017,23(01):113-115.
[24] 敖慧,葉強(qiáng)*,徐艷文,魏擔(dān),豆彩霞,劉紅梅,方成鑫.基于GC-MS技術(shù)的陽(yáng)春砂仁煎煮方式的篩選[J].中藥新藥與臨床藥理,2016,27(05):705-708.
[25] 敖慧,劉紅梅,王江瑞,方成鑫,許莉,郭力,彭成,葉強(qiáng).不同產(chǎn)地砂仁的揮發(fā)油GC-MS分析及重金屬殘留測(cè)定[J].中藥新藥與臨床藥理,2016,27(02):250-254.
[26] 李生茂,葉強(qiáng),敖慧.砂仁揮發(fā)油GC-MS指紋圖譜與其鎮(zhèn)痛作用的關(guān)系[J].中成藥,2016,38(02):346-350.