彭成
個(gè)人簡介
彭成,博士,研究員,博士/碩士研究生導(dǎo)師,原成都中醫(yī)藥大學(xué)副校長,國家“雙一流”建設(shè)學(xué)科中藥學(xué)學(xué)科帶頭人、國務(wù)院學(xué)位委員會(huì)中藥學(xué)科評議組成員、中華人民共和國《藥典》委員會(huì)委員、全國高等中醫(yī)藥院校藥學(xué)類規(guī)劃教材編委會(huì)主任委員、世界中醫(yī)藥聯(lián)合會(huì)道地藥材多維評價(jià)專委會(huì)理事長、中國中藥協(xié)會(huì)中藥材檢測與認(rèn)證專家委員會(huì)主任委員、國務(wù)院政府津貼獲得者、新世紀(jì)百千萬人才工程國家級人選、國家衛(wèi)生計(jì)生突出貢獻(xiàn)中青年專家、國家中醫(yī)藥管理局中醫(yī)藥傳承與創(chuàng)新“百千萬”人才工程(岐黃工程)岐黃學(xué)者。
研究方向:中藥學(xué)(疾病動(dòng)物模型與中藥藥理毒理研究),方劑學(xué)(脾胃證治方藥研究)。近年來承擔(dān)國家“973”計(jì)劃課題、國家支撐計(jì)劃重點(diǎn)項(xiàng)目、國家創(chuàng)新藥物重大專項(xiàng)任務(wù)、國家自然科學(xué)基金重點(diǎn)項(xiàng)目和等國家級項(xiàng)目30多項(xiàng);獲國家科技進(jìn)步二等獎(jiǎng)2項(xiàng)(負(fù)責(zé)1項(xiàng)),國家中醫(yī)藥科技進(jìn)步二等獎(jiǎng)1項(xiàng)(負(fù)責(zé)),四川省科技進(jìn)步一等獎(jiǎng)7項(xiàng)(負(fù)責(zé)6項(xiàng)),國家教學(xué)成果二等獎(jiǎng)1項(xiàng)(負(fù)責(zé)),四川省教學(xué)成果一等獎(jiǎng)3項(xiàng)(負(fù)責(zé));發(fā)表SCI 論文200多篇,影響因子5.0分以上逾30篇;參加國際特邀學(xué)術(shù)報(bào)告20多次;主編“十二五”“十三五”國家重點(diǎn)圖書等專著和教材20多部;獲國家發(fā)明專利授權(quán) 30 多項(xiàng),培養(yǎng)博士后20人、博士研究生59人、碩士生75人。主要學(xué)術(shù)成就:針對國際民生的大事“中藥安全性問題”,提出并建立有毒中藥“毒性物質(zhì)基礎(chǔ)-毒作用機(jī)制-控毒方法體系”的安全性評價(jià)模式,成為中藥毒性研究的主要模式,具有開拓性;針對中藥創(chuàng)新藥物研究的關(guān)鍵問題,研究、發(fā)現(xiàn)、開發(fā)創(chuàng)新中藥,具有創(chuàng)新性;以道地藥材為研究對象,提出中藥“品質(zhì)制性效用”多維評價(jià)模式,開展中藥大品種的系統(tǒng)研究和綜合利用,對中成藥大品種進(jìn)行二次研究開發(fā),產(chǎn)生顯著經(jīng)濟(jì)成果。
代表性成果
(1)主持的代表性國家項(xiàng)目
1.國家自然科學(xué)基金委員會(huì),區(qū)域創(chuàng)新發(fā)展聯(lián)合基金,U19A2010,川產(chǎn)道地藥材的道地性研究,2020-01至2023-12,247萬元
2.國家自然科學(xué)基金委員會(huì),重大項(xiàng)目課題,81891012,中藥道地性“性-效”關(guān)系研究,2019-01至2023-12
3. 國家自然科學(xué)基金委員會(huì),重點(diǎn)項(xiàng)目,81630101,附子“毒與效”的多維評價(jià)與整合分析研究,2019-01至2021-12
4.國家科技部,重大新藥創(chuàng)制,2018ZX09721001-008,中藥及天然產(chǎn)物防治耐藥菌創(chuàng)新藥物發(fā)現(xiàn)及新品種研發(fā),2018.01-2021.12
(2)代表性論文
1. Dan Li, Tian Zhang, Jinjian Lu, Cheng Peng*, Ligen Lin*. Natural constituents from food sources as therapeutic agents for obesity and metabolic diseases targeting adipose tissue inflammation[J]. Critical Reviews In Food Science and Nutrition, 2020, 1-19. doi:10.1080/10408398.2020.1768044. (IF=7.862)
2. Yue Han, Jiutai Wang, Qiuying Zhao, Xiaofang Xie, Rui Song, Ying Xiao, Xixi Kang, Lijuan Zhang, Yue Zhang, Cheng Peng*, Zili You*. Pioglitazone alleviates maternal sleep deprivation-induced cognitive deficits in male rat offspring by enhancing microglia-mediated neurogenesis[J]. Brain Behavior and Immunity, 2020, 87: 568-578. (IF= 6.633)
3. Yu Liu, Fei Liu, Ming-Ming Qiao, Li Guo, Ming-Hua Chen, Cheng Peng*, Liang Xiong*. Curcumanes A and B, two bicyclic sesquiterpenoids with unprecedented skeletons and significant vasorelaxant activity from Curcuma longa[J]. Organic Letters, 2019, 21(4): 1197-1201. (IF=6.555)
4. Jun-Long Li, Lu Fu, Jiao Wu, Kai-Chuan Yang, Qing-Zhu Li, Xiao-Jun Gou, Cheng Peng*, Bo Han, Xu-Dong Shen*. Highly enantioselective synthesis of fused bicyclic dihydropyranones via low-loading N-heterocyclic carbene organocatalysis[J].Chemical Communications, 2017, 53(51): 6875-6878. (IF=6.164)
5. Qiuying Zhao, Xiaohui Wu, Shuo Yan, Xiaofang Xie, Yonghua Fan, Jinqiang Zhang, Cheng Peng*, Zili You*. The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPARγ-mediated alteration of microglial activation phenotypes[J]. Journal of Neuroinflammation, 2016, 13(1): 259. (IF=5.7)
6. Wuwen Feng, Hui Ao, Cheng Peng*, Dan Yan*. Gut microbiota, a new frontier to understand traditional Chinese medicines[J]. Pharmacological Research, 2019, 142:176-191. (IF=5.574)
7. Chuanjie Guo, Junlin He, Xiaominting Song, Lu Tan, Miao Wang, Peidu Jiang, Yuzhi Li, Zhixing Cao*, Cheng Peng*. Pharmacological properties and derivatives of shikonin-A review in recent years[J]. Pharmacological Research, 2019, 149: 104463.(IF=5.574)
8. Xin Xie, Wei Huang, Cheng Peng*, Bo Han*. Organocatalytic Asymmetric Synthesis of Six-Membered Carbocycle-Based Spiro Compounds[J]. Advanced Synthesis and Catalysis, 2018, 360(2): 194-228.(IF=5.646)
9. He Yang, Peng Fu, Deng Cao, Xiong Liang, Huang Ziyan, Zhang Ruoqi, Liu mengjia, Peng Cheng*. Building an octaploid genome and transcriptome of the medicinal plant posostemon cabin from lamiales[J]. Scientific Data, 2018. (doi: 10.1038/sdata.2018.274.) (IF=5.541)
10. Nan Zhang, Zhong Zhou, Yujia Wang, Yang Li, Fengbo Wu, Cheng Peng, Wei Huang*, Gu He*. Competing endogenous network analysis identifies lncRNA Meg3 activates inflammatory damage in UVB induced murine skin lesion by sponging miR-93-5p/epiregulin axis[J]. Aging-US, 2019, 11(22): 10664-10683. (IF=5.515)
11. Yu-Zhi Li#, Si Yu#, Pei-Ao Yan, Dao-Yin Gong, Fang-Li Wu, Zhi He, Yu-Yao Yuan, An-Yan Zhao, Xue Tang, Ruo-Qi Zhang, Cheng Peng*, Zhi-Xing Cao*. Crotonoside exhibits selective post-inhibition effect in AML cells via inhibition of FLT3 and HDAC3/6[J]. Oncotarget, 2017, 8(61): 103087-103099. (IF=5.168)