劉燕
一、個(gè)人簡(jiǎn)介
教授，博士/碩士導(dǎo)師，國(guó)家優(yōu)秀青年基金獲得者?，F(xiàn)為成都中醫(yī)藥大學(xué)中醫(yī)藥創(chuàng)新研究院/交叉學(xué)科研究院副院長(zhǎng)。入選中組部“西部之光”青年學(xué)者（A類）、中科院青年創(chuàng)新促進(jìn)會(huì)會(huì)員、四川省杰出青年科技人才、四川省引進(jìn)高層次青年人才、云南省“萬(wàn)人計(jì)劃”等。主要學(xué)術(shù)兼職包括中國(guó)中藥協(xié)會(huì)中藥材檢測(cè)認(rèn)證技術(shù)專業(yè)委員會(huì)委員、中國(guó)生態(tài)學(xué)學(xué)會(huì)化學(xué)生態(tài)專業(yè)委員會(huì)委員、The Innovation青年編委、Natural Product & Bioprospecting青年編委等。
研究方向：藥用植物活性天然產(chǎn)物形成機(jī)制與合成生物學(xué)
招生專業(yè)：中藥資源學(xué)
聯(lián)系電話：15087166860
郵箱：liuyan@cdutcm.edu.cn
二、研究領(lǐng)域
長(zhǎng)期從事藥用植物活性天然產(chǎn)物形成機(jī)制與合成生物學(xué)研究，主持國(guó)家自然科學(xué)基金優(yōu)秀青年基金、NSFC-云南聯(lián)合基金重點(diǎn)等國(guó)家級(jí)和省部級(jí)科研項(xiàng)目10余項(xiàng)。建立“合成生物學(xué)-多組學(xué)-中藥化學(xué)”中藥生物合成基因高效發(fā)掘體系，解析名貴中藥重樓活性成分稀有重樓皂苷連續(xù)糖基化生物合成的6個(gè)糖基轉(zhuǎn)移酶PpUGT1-6及催化機(jī)制，發(fā)現(xiàn)重樓皂苷顯著抗皮膚癬菌活性與初步作用機(jī)制；鑒定佤藥/基諾藥米團(tuán)花中二倍半萜生物合成關(guān)鍵酶GFDPS，填補(bǔ)了國(guó)際上半個(gè)世紀(jì)以來(lái)對(duì)該類重要活性天然產(chǎn)物生物合成途徑認(rèn)識(shí)的空白；鑒定首個(gè)催化合成最大碳環(huán)骨架二倍半萜的新穎萜類合酶LcTPS2，發(fā)現(xiàn)產(chǎn)物顯著抗炎免疫活性和作用機(jī)制；從白族藥火把花中鑒定首個(gè)高度雜泛植物萜類合酶CcTPS1，為揭示藥用植物物質(zhì)基礎(chǔ)多樣性和復(fù)雜性成因提供科學(xué)依據(jù)；從滇南常用草藥中發(fā)現(xiàn)高性能杜松烯合酶基因，實(shí)現(xiàn)了重要天然產(chǎn)物杜松烯高效異源合成。建立藥用植物生物合成特色元件庫(kù)，庫(kù)容元件超過(guò)200個(gè)。以第一/通訊作者在Angewandte Chemie International Edition、Plant Cell (封面文章)、Acta Pharmaceutica Sinica B、Natural Product Reports等發(fā)表SCI論文30余篇，包括中科院一區(qū)論文9篇，獲省部級(jí)自然科學(xué)一等獎(jiǎng)1項(xiàng)，獲授權(quán)發(fā)明專利4項(xiàng)。
三、代表性成果
1) Yuegui Chen#, Desen Li#, Yi Ling#, Yanchun Liu, Zhili Zuo, Lishe Gan, Shihong Luo, Juan Hua, Dingyuan Chen, Fan Xu, Man Li, Kai Guo, Yan Liu*, Jonathan Gershenzon, Shenghong Li*. A cryptic plant terpene cyclase producing unconventional 18- and 14-membered macrocyclic C25 and C20 terpenoids with immunosuppressive activity. Angewandte Chemie International Edition, 2021, 60: 25468–25476.
2) Yuegui Chen#, Qin Yan#, Yunheng Ji, Xue Bai, Desen Li, Rongfang Mu, Kai Guo, Minjie Yang, Yang Tao, Jonathan Gershenzon, Yan Liu*, Shenghong Li*. Unraveling the serial glycosylation in the biosynthesis of steroidalsaponins in the medicinal plant Paris polyphylla and their antifungal action. Acta Pharmaceutica Sinica B, 2023, 13: 4638-4654 (cover article).
3) Yan Liu#, Shihong Luo#, Juan Hua, Desen Li, Yi Ling, Qian Luo, Shenghong Li*. Characterization of defensive cadinenes and a novel sesquiterpene synthase responsible for their biosynthesis from the invasive Eupatorium adenophorum. New Phytologist, 2021, 229: 1740–1754.
4) Yan Liu, Shihong Luo, Axel Schmidt, Guodong Wang, Guiling Sun, Marcus Grant, Ce Kuang, Minjie Yang, Shuxi Jing, Chunhuan Li, Bernd Schneider, Jonathan Gershenzon, Shenghong Li*. A geranylfarnesyl diphosphate synthase provides the precursor for sesterterpenoid (C25) formation in the glandular trichomes of the mint species Leucosceptrum canum, Plant Cell, 2016, 28: 804–822 (cover article).
5) Yan Liu, Shuxi Jing, Shihong Luo, Shenghong Li*. Non-volatile natural products in plant glandular trichomes: chemistry, biological activities and biosynthesis. Natural Product Reports, 2019, 36: 626–665.
6) Desen Li, Juan Hua, Shihong Luo, Yanchun Liu, Yuegui Chen, Yi Ling, Kai Guo, Yan Liu*, Shenghong Li*. An extremely promiscuous terpenoid synthase from the Lamiaceae plant Colquhounia coccinea var. mollis catalyzes the formation of sester-/di-/sesqui-/mono-terpenoids. Plant Communications, 2021, 2: 100233 (cover article).
7) Desen Li, Minjie Yang, Rongfang Mu, Shihong Luo, Yuegui Chen, Wenyuan Li, An Wang, Kai Guo, Yan Liu*, Shenghong Li*. Characterization of two chimeric sesterterpene synthases from a fungal symbiont isolated from a sesterterpenoid-producing Lamiaceae plant Leucosceptrum canum. Chinese Chemical Letters, 2023, 34: 107469.
8) Kai Guo#, Yan Liu#, Shenghong Li*. The untapped potential of plant sesterterpenoids: chemistry, biological activities and biosynthesis. Natural Product Reports, 2021, 38: 2293–2314.
9) Chunhuan Li#, Yan Liu#, Juan Hua, Shihong Luo, Shenghong Li*. Peltate glandular trichomes of Colquhounia seguinii harbor new defensive clerodane diterpenoids. Journal of Integrative Plant Biology, 2014, 56: 928–940.
10) Desen Li, Linlin Shi, Kai Guo, Shihong Luo, Yanchun Liu, Yuegui Chen, Yan Liu*, Shenghong Li*. “A new sesquiterpene synthase catalyzing the formation of (R)-β-bisabolene from medicinal plant Colquhounia coccinea var. mollis and its anti-adipogenic and antibacterial activities”, Phytochemistry, 2023, 211, 113681.