張梅
一、個人簡介
張梅，博士，教授，博士生導師，成都中醫(yī)藥大學藥學院中藥化學系教師，四川省學術和技術帶頭人后備人選，四川省精品課程—《中藥制劑分析》負責人?，F(xiàn)任世界中醫(yī)藥學會聯(lián)合會道地藥材專委會常務理事，中華中醫(yī)藥學會中藥分析分會常務委員，四川省分析測試學會色譜學委員會副主任委員。一直從事中藥物質(zhì)基礎及中藥質(zhì)量控制與評價等方面的教學及科研工作，作為課題負責人及主研人員承擔了國家自然科學基金及部省局級科研項目近40項，獲得授權發(fā)明專利5項，作為主持人及第二主研獲得四川省和成都市科技進步三等獎共3項。圍繞以上研究工作在相關雜志及學術會議上公開發(fā)表及交流論文150余篇。作為主編、副主編及編委參與編寫《當代藥用植物典》系列專著及國家“十四·五”、“十三·五”、“十二·五”、“十一·五”、“十·五”等規(guī)劃教材及教參20余部。
研究領域涉及（1）中藥物質(zhì)基礎及作用機制研究；（2）中藥質(zhì)量控制及評價方法研究；（3）中藥分析新方法及新技術研究；（4）中藥體內(nèi)藥物及其代謝產(chǎn)物分析，等。
近年來專注于防治糖尿病視網(wǎng)膜病變（Diabetic retinopathy, DR）有效中藥復方藥效物質(zhì)基礎及作用機制的研究，獲得5項國家自然基金項目及國家教育部、四川省科技廳等多項基金資助，在Natural Product Reports、Sensors and Actuators B: Chemical、Food Chemistry （中科院1區(qū)）、Journal of Ethnopharmacology、Microchemical Journal.、Biomedicine & Pharmacotherapy（中科院2區(qū)）等期刊上以通訊作者發(fā)表學術論文30余篇。
二、招生專業(yè)
代碼 | 二級學科 | 所屬學院 |
1008Z4 | 中藥化學 | 藥學院 |
100800 | 中藥分析 | 藥學院 |
三、代表性成果
(1) Jia Wang, Fangyong Wei, Yu Wang, Qingze Liu, Runxi He, Yuxia Huang, Kuang Wei, Xuejun Xie*, Mei Zhang*. Exploring the quality markers and mechanism of Bushen Huoxue Prescription in prevention and treatment of diabetic retinopathy based on Chinmedomics strategy. Journal of Ethnopharmacology. DOI: 10.1016/j.jep.2022.116131
(2) Yuxia Huang, Jia Wang, Yu Wang, Wei Kuang, Mengjun Xie*, Mei Zhang*.Pharmacological mechanism and clinical study of Qiming granules in treating diabetic retinopathy based on network pharmacology and literature review. Journal of Ethnopharmacology. DOI: 10.1016/j.jep.2022.115861
(3) Haiyan Yang, Kejun Li, Yanping Wang, Xin Yuan*, Mei Zhang*. A label-free strategy for H2O2 assay by chemical vapor generation-atomic ?uorescence spectrometry. Microchemical Journal. DOI: 10.1016/j.microc.2022.107965
(4) Liangli Li, Maohua Yang, Mei Zhang*, Mingyan Jia*. Inkjet-printed colorimetric sensor array for the rapid identifcation of adulterated Fritillariae cirrhosae bulbus. Sensors & Actuators: B. Chemical. DOI: 10.1016/j.snb.2022.132210
(5) Lulin Peng, Maohua Yang, Mei Zhang*, Mingyan Jia*. A ratiometric ?uorescent sensor based on carbon dots for rapid determination of bisulfte in sugar. Food Chemistry. DOI: 10.1016/j.foodchem.2022.133265.
(6) Yueting Yu, Ziyu Zhu, Mengjun Xie, Liping Deng, Xuejun Xie*, Mei Zhang*. Investigation on the Q-markers of Bushen Huoxue Prescriptions for DR treatment based on chemometric methods and spectrum-effect relationship. Journal of Ethnopharmacology. DOI: 10.1016/j.jep.2021.114800
(7) Chen Yang, Lan Lu, Li Liao, Bin Zhang, Min Zeng, Kun Zou, Xia Liu, Mei Zhang*. Establishment of GC–MS method for the determination of Pseudomonas aeruginosa biofilm and its application in metabolite enrichment analysis. Journal of Chromatography B. DOI: 10.1016/j.jchromb. 2021.122839
(8) Kejun Li, Haiyan Yang, Xin Yuan*, Mei Zhang*. A novel and indirect method for L-cysteine detection in traditional Chinese medicines by chemical vapor generation-atomic fluorescence spectrometry. Microchemical Journal. DOI: 10.1016/j.microc.2021.106891.
(9) Miao Zeng, Longkai Qi, Yinrui Guo, Xiangxiang Zhu, Xiaocui Tang, Tianqiao Yong, Yizhen Xie, Qingping Wu, Mei Zhang*and Diling Chen*.Long-Term Administration of Triterpenoids From Ganoderma lucidum Mitigates Age-Associated Brain Physiological Decline via Regulating Sphingolipid Metabolism and Enhancing Autophagy in Mice. Frontiers in Aging Neuroscience. DOI: 10.3389/fnagi.2021.628860
(10) Mengjun Xie, Yueting Yu, Ziyu Zhu, Liping Deng, Bo Ren*, Mei Zhang*. Simultaneous determination of six main components in BushenHuoxue prescription by HPLC-CAD. Journal of Pharmaceutical and Biomedical Analysis. DOI: 10.1016/j.jpba.2021.114087
(11) Dan Cai, JiaoJiao Zhang, ZeHong Wu, FuYing Qin, YongMing Yan, Mei Zhang*, YongXian Cheng*. Lucidumones B-H, racemic meroterpenoids that inhibit tumor cell migration from Ganoderma lucidum. Bioorganic Chemistry. DOI: 10.1016/j.bioorg.2021.104774
(12) Kejun Li, Haiyan Yang, Xin Yuan*, Mei Zhang*. Recent developments of heavy metals detection in traditional Chinese medicine by atomic spectrometry. Microchemical Journal. DOI: 10.1016/j.microc.2020.105726
(13) Mengjun Xie, Liping Deng , Yueting Yu , Xuejun Xie,*, Mei Zhang*. The effects of Bushen Yiqi Huoxue prescription and its disassembled prescriptions on a diabetic retinopathy model in Sprague Dawley rats. Biomedicine & Pharmacotherapy. DOI: 10.1016/j.biopha.2020.110920
(14) Mingyan Jia*，Yixuan Pan，Jianbo Zhou，Mei Zhang*. Identification of Chinese teas by a colorimetric sensor array based on tea polyphenol induced indicator displacement assay. Food Chemistry. DOI: 10.1016/j.foodchem.2020.127566
(15) Yang Li, Yanru Zhang, Bo Cao, Fengqin Zhang, Ming Niu, Xue Bai, Mei Zhang*, Haizhu Zhang*. Screening for the antiplatelet aggregation quality markers of Salvia yunnanensis based on an integrated approach. Journal of Pharmaceutical and Biomedical Analysis. DOI：10.1016/j.jpba.2020.113383