熊亮
熊亮，男，博士，博士后，研究員（二級(jí)教授），博士生導(dǎo)師，畢業(yè)于北京協(xié)和醫(yī)學(xué)院&中國(guó)醫(yī)學(xué)科學(xué)院藥物研究所，現(xiàn)任成都中醫(yī)藥大學(xué)藥學(xué)院/現(xiàn)代中藥產(chǎn)業(yè)學(xué)院副院長(zhǎng)、西南特色藥材創(chuàng)新藥物成分研究所所長(zhǎng)。國(guó)家“優(yōu)秀青年科學(xué)基金”獲得者、四川省學(xué)術(shù)技術(shù)帶頭人、省部級(jí)優(yōu)秀人才計(jì)劃入選者、四川省杰出青年基金獲得者、四川省中醫(yī)藥管理局學(xué)術(shù)和技術(shù)帶頭人等。現(xiàn)為世界中聯(lián)中藥上市后再評(píng)價(jià)專業(yè)委員會(huì)常務(wù)理事、中國(guó)民族醫(yī)藥學(xué)會(huì)信息與大數(shù)據(jù)分會(huì)常務(wù)理事、中國(guó)研究型醫(yī)院學(xué)會(huì)中西醫(yī)結(jié)合新藥創(chuàng)制專業(yè)委員會(huì)常務(wù)委員、中華中醫(yī)藥學(xué)會(huì)青年委員、中華中醫(yī)藥學(xué)會(huì)中醫(yī)藥防治重大疾病基礎(chǔ)研究平臺(tái)專家委員會(huì)委員、國(guó)家自然科學(xué)基金評(píng)審專家、教育部學(xué)位論文評(píng)審專家、四川省專家評(píng)議（審）委員會(huì)委員、四川省科技評(píng)審專家、Front. Chem.副主編、Chin. J. Nat. Med., World J. Tradit. Chin. Med., Chin. Med. Cult.青年編委等。
致力于活血化瘀中藥治療婦科疾病和心腦血管疾病的物質(zhì)基礎(chǔ)及作用機(jī)制研究。近年來(lái)，選擇西南地區(qū)豐富的活血化瘀中藥開(kāi)展現(xiàn)代研究，如“經(jīng)產(chǎn)良藥”益母草、“上行頭目、下達(dá)血海”川芎、“氣中血藥”姜黃與莪術(shù)、“化舊生新良藥”山莨菪、“通經(jīng)止痛要藥”紅花等。主持主研國(guó)家自然科學(xué)基金重大項(xiàng)目、重點(diǎn)項(xiàng)目、優(yōu)秀青年基金、面上項(xiàng)目、青年基金、霍英東基金、國(guó)家重大新藥創(chuàng)制專項(xiàng)、國(guó)家中藥標(biāo)準(zhǔn)化項(xiàng)目、四川省杰出青年基金、中國(guó)博士后科學(xué)基金、四川省科技創(chuàng)新人才項(xiàng)目等40余項(xiàng)；發(fā)表論文170余篇，其中以第一作者或通訊作者發(fā)表SCI論文60余篇，出版專著7部（含十三五、十四五規(guī)劃教材3部），獲授權(quán)發(fā)明專利25項(xiàng)（含歐洲專利2項(xiàng)），轉(zhuǎn)化9項(xiàng)；獲四川省科技進(jìn)步一等獎(jiǎng)，中醫(yī)藥國(guó)際貢獻(xiàn)獎(jiǎng)-科技進(jìn)步二等獎(jiǎng)，華夏醫(yī)學(xué)科技獎(jiǎng)二等獎(jiǎng)。
近5年代表性SCI論文（2018-2022）
(1) Pocahemiketone A, a sesquiterpenoid possessing a spirocyclic skeleton with a hemiketal endoperoxide unit, alleviates Aβ25?35-induced pyroptosis and oxidative stress in SH-SY5Y cells. Organic Letters, 2022, 24: 4734?4738 (通訊作者)
(2) Sesquiterpenoids from the florets of Carthamus tinctorius (Safflower) and their anti-Atherosclerotic activity. Nutrients, 2022, 14, 5348 (通訊作者)
(3) Six pairs of enantiomeric phthalide dimers from the rhizomes of Ligusticum chuanxiong and their absolute configurations and anti-inflammatory activities. Bioorganic Chemistry, 2022, 127: 105970 (通訊作者)
(4) Vasorelaxant effect of curcubisabolanin A isolated from Curcuma longa through the PI3K/Akt/eNOS signaling pathway. Journal of Ethnopharmacology, 2022, 294: 115332 (通訊作者)
(5) Curcumanes E and F, two rare sesquiterpenoids with a dicyclo[3.3.1]nonane moiety, from Curcuma longa and their vasorelaxant activities. Frontiers in Chemistry, 2022, 10: 995950 (通訊作者)
(6) Isoindolines and phthalides from the rhizomes of Ligusticum chuanxiong and their relaxant effects on the uterine smooth muscle. Phytochemistry, 2022, 198: 113159 (通訊作者)
(7) Antiproliferative and proapoptotic effects of phenanthrene derivatives isolated from Bletilla striata on A549 lung cancer cells. Molecules, 2022, 27: 3519 (通訊作者)
(8) Bioactive neolignans and lignans from the roots of Paeonia lactiflora. Chinese Journal of Natural Medicines, 2022, 20: 1-5 (通訊作者)
(9) Discovery of bletillain, an unusual benzyl polymer with significant autophagy-inducing effects in A549 lung cancer cells through the Akt/GSK-3β/β-catenin signaling pathway. Bioorganic Chemistry, 2021, 117: 105449 (通訊作者)
(10) New lignans from the fruits of Leonurus japonicus and their hepatoprotective activities. Bioorganic Chemistry, 2021, 115: 105252 (通訊作者)
(11) Recent research and development of NDM-1 inhibitors. European Journal of Medicinal Chemistry, 2021, 223: 113667 (通訊作者)
(12) Anisotanols A—D, four norsesquiterpenoids with an unprecedented sesquiterpenoid skeleton from Anisodus tanguticus. Chinese Journal of Chemistry, 2021, 39: 3375-3380 (通訊作者)
(13) Chemical composition and uterine smooth muscle relaxant activity of essential oils from 10 kinds of blood-activating and stasis-resolving Chinese medicinal herbs. Journal of Ethnopharmacology, 2021, 269: 113713 (通訊作者)
(14) Twelve undescribed derivatives of ganoderic acid isolated from Ganoderma luteomarginatum and their cytotoxicity against three human cancer cell lines. Phytochemistry, 2021, 183: 112617 (通訊作者)
(15) Polyacetylene glucosides from the ?orets of Carthamus tinctorius and their anti-in?ammatory activity. Phytochemistry, 2021, 187: 112770 (通訊作者)
(16) Bisabolane-type sesquiterpenoids: Structural diversity and biological activity. Phytochemistry, 2021, 192: 112927 (通訊作者)
(17) Cardioprotective effects and concentration-response relationship of aminoalcohol-diterpenoid alkaloids from Aconitum carmichaelii. Fitoterapia, 2021, 149: 104822 (通訊作者)
(18) Seven pairs of new enantiomeric sesquiterpenoids from Curcuma phaeocaulis. Bioorganic Chemistry, 2020, 99: 103820 (通訊作者)
(19) Stachydrine promotes angiogenesis by regulating the VEGFR2/MEK/ERK and mitochondrial-mediated apoptosis signaling pathways in human umbilical vein endothelial cells. Biomedicine & Pharmacotherapy, 2020, 131: 110724 (通訊作者)
(20) Traditional Chinese medicine formulas, extracts, and compounds promote angiogenesis. Biomedicine & Pharmacotherapy, 2020, 132: 110855 (通訊作者)
(21) Curcumanes A and B, Two Bicyclic Sesquiterpenoids with Significant Vasorelaxant Activity from Curcuma longa. Organic Letters, 2019, 21: 1197-1201 (通訊作者)
(22) Curcumane C and (±)-curcumane D, an unusual seco-cadinane sesquiterpenoid and a pair of unusual nor-bisabolane enantiomers with significant vasorelaxant activity from Curcuma longa. Bioorganic Chemistry, 2019, 92: 103275 (通訊作者)
(23) Leonurus japonicus (Chinese motherwort), an excellent traditional medicine for obstetrical and gynecological diseases: A comprehensive overview. Biomedicine & Pharmacotherapy, 2019, 117: 109060 (通訊作者)
(24) Cytotoxicity of lanostane-type triterpenoids and ergosteroids isolated from Omphalia lapidescens on MDA-MB-231 and HGC-27 cells. Biomedicine & Pharmacotherapy, 2019, 118: 109273 (通訊作者)
(25) Alkaloids from the rhizomes of Ligusticum striatum exert antimigraine effects through regulating 5-HT1B receptor and c-Jun. Journal of Ethnopharmacology, 2019, 237: 39-46 (通訊作者)
(26) Discrimination of the Geographical Origin of the Lateral Roots of Aconitum carmichaelii Using the Fingerprint, Multicomponent Quantification, and Chemometric Methods. Molecules, 2019, 24: 4124 (通訊作者)
(27) New sesquiterpenoids from the stems of Dendrobium nobile and their neuroprotective activities. Fitoterapia, 2019,138: 104351 (通訊作者)
(28) Absolute Configurations and Bioactivities of Guaiane-Type Sesquiterpenoids Isolated from Pogostemon cablin. Journal of Natural Products, 2018, 81: 1919-1927 (通訊作者)
(29) Alkaloids and flavonoid glycosides from the aerial parts of Leonurus japonicus and their opposite effects on uterine smooth muscle. Phytochemistry, 2018, 145: 128-136 (通訊作者)
(30) Lanostane triterpenoids from Ganoderma luteomarginatum and their cytotoxicity against four human cancer cell lines. Phytochemistry, 2018, 156: 89-95 (通訊作者)
代表性專著教材
(1)熊亮（副主編）. 天然藥物化學(xué)（全國(guó)普通高等中醫(yī)藥院校藥學(xué)類專業(yè)“十三五”規(guī)劃教材-第二輪規(guī)劃教材）, 中國(guó)醫(yī)藥科技出版社, 2018/8, 北京.
(2)熊亮（編委）. 中藥化學(xué)（全國(guó)中醫(yī)藥行業(yè)高等教育“十四五”規(guī)劃教材-全國(guó)高等中醫(yī)藥院校規(guī)劃教材）, 中國(guó)中醫(yī)藥出版社, 2021/6, 北京.
(3)熊亮（編委）. 天然藥物化學(xué)實(shí)驗(yàn)（全國(guó)普通高等中醫(yī)藥院校藥學(xué)類專業(yè)“十三五”規(guī)劃教材-第二輪規(guī)劃教材）, 中國(guó)醫(yī)藥科技出版社, 2018/8, 北京.
(4)熊亮（副主編）. 經(jīng)產(chǎn)良藥益母草, 四川科學(xué)技術(shù)出版社, 2017/11, 成都.
獲得獎(jiǎng)勵(lì)
(1) 益母草全產(chǎn)業(yè)鏈關(guān)鍵技術(shù)創(chuàng)新與產(chǎn)品開(kāi)發(fā)應(yīng)用示范，2019年度中醫(yī)藥國(guó)際貢獻(xiàn)獎(jiǎng)-科技進(jìn)步獎(jiǎng)，二等獎(jiǎng)
(2) 經(jīng)產(chǎn)良藥益母草的多維評(píng)價(jià)與開(kāi)發(fā)應(yīng)用，2017年度四川省科技進(jìn)步獎(jiǎng)，一等獎(jiǎng)
(3) 烏頭類有毒中藥安全性評(píng)價(jià)模式的建立與示范，2013年度華夏醫(yī)學(xué)科技獎(jiǎng)，二等獎(jiǎng)