郭力
一、個人簡介
博士，教授，博士生導(dǎo)師，國務(wù)院特殊津貼專家，四川省學(xué)術(shù)和技術(shù)帶頭人，四川省中醫(yī)藥學(xué)術(shù)和技術(shù)帶頭人，四川省有突出貢獻(xiàn)優(yōu)秀專家。長期從事中藥化學(xué)成分與中藥質(zhì)量標(biāo)準(zhǔn)化研究，探索和闡明中藥藥效物質(zhì)基礎(chǔ)，重點(diǎn)圍繞川產(chǎn)道地藥材附子、川烏、石斛、熊膽粉等品種的化學(xué)成分、炮制、配伍、藥理活性等多方面研究，對建立其質(zhì)量控制體系進(jìn)行了積極探索。研發(fā)新藥及健康產(chǎn)品10余項(xiàng)，主持多項(xiàng)科研課題，授權(quán)專利10余項(xiàng)，出版專著20余部，發(fā)表論文百余篇，其中SCI論文50余篇，包括《Biomaterials》、《European Journal of Medicinal Chemistry》、《Phytochemical Analysis》、《Chemical Record》等著名期刊；培養(yǎng)碩博研究生50余名。
二、代表性成果（可含承擔(dān)項(xiàng)目、發(fā)表論文、論著、獲獎等）
一）項(xiàng)目
1. 國家科技部，國家重點(diǎn)研發(fā)項(xiàng)目子課題，2017YFC1701804，高品質(zhì)道地藥材中藥材附子規(guī)模化種植及精準(zhǔn)扶貧示范研究，2018.01-2021-12, 37.5萬元，結(jié)題，主持
2. 四川省科技廳，四川省科技基礎(chǔ)條件平臺項(xiàng)目，2019JDPT0032，四川省中藥化合物資源共享平臺，2019.01-2021.12, 12.5萬元，結(jié)題，主持
3. 國家自然科學(xué)基金，區(qū)域創(chuàng)新發(fā)展聯(lián)合基金，U19A2010，川產(chǎn)道地藥材的道地性研究，2020.01-2023.12, 247萬元，在研，主研
4. 橫向課題，熊膽、梅花鹿系列產(chǎn)品研究開發(fā)，成都晶博生物科技有限責(zé)任公司，2020.07-2022.07, 120萬元，在研，主持
二）論文
1. Xiao Haijun#; Guo Yiping#; Liu Hongmei; Liu Yushi; Wang Yumin; Li Changqing; Jaroslav Císa?; David ?koda; Ivo Ku?itka; Guo Li*; Vladimír Sedlar?íkp*; Structure-based design of charge-conversional drug self-delivery systems for better targeted cancer therapy, Biomaterials, 2020, 232.
2. Li He#; Qian Su#; Lan Bai#; Meifeng Li; Juanru Liu; Xiaomei Liu; Cunyan Zhang; Zhongliang Jiang; Jun He; Jianyou Shi*; Shan Huang*; Li Guo*; Recent research progress on natural small molecule bibenzyls and its derivatives in Dendrobium species, European Journal of Medicinal Chemistry, 2020, 112530.
3. Zhang Zhen##; Jiang Maoyuan#; Wei Xinyi; Shi Jingfeng; Geng Zhao; Yang Shasah; Fu Chaomei*; Guo Li*; Rapid discovery of chemical constituents and absorbed components in rat serum after oral administration of Fuzi-Lizhong pill based on high-throughput HPLC-Q-TOF/MS analysis, Chinese Medcine, 2019, 14(6): 1-22.
4. Liu Hongmei; Fang Chengxin; Zhang Tingmo; Guo Li*; Ye Qiang*; Molecular authentication and differentiation of Dendrobium species by rDNA ITS region sequence analysis, AMB Express, 2019, 9(53): 1-9
5. Ye Qiang; Liu Hongmei; Fang Chengxin; Liu Yushi; Liu Xiaomei; Liu Juanru; Zhang Cunyan; Zhang Tingmo; Peng Cheng*; Guo Li*; Cardiotoxicity evaluation and comparison of diterpene alkaloids on zebrafish, Drug and Chemical Toxicology, 2019: 1-8.
6. Zhang Xiao; Zou, Lihua; He Yulin; Peng Cheng; Guo Li*; Xiong Liang*. Triterpenoid saponins from the buds of Lonicera similis. Natural Product Research, 2018, 32: 2282-2290.
7. Liu YS, Yuan MH, Zhang CY, Liu HM, Liu JR, Wei AL, Ye Q, Zeng B, Li MF, Guo YP, Guo L*. Puerariae Lobatae radix flavonoids and puerarin alleviate alcoholic liver injury in zebrafish by regulating alcohol and lipid metabolism. Biomed Pharmacother. 2021; 134:111121.
8. Liu H, Yuan M, Liu Y, Guo Y, Xiao H, Guo L*, Liu F. Self-Monitoring and Self-Delivery of Self-Assembled Fluorescent Nanoparticles in Cancer Therapy. Int J Nanomedicine. 2021; 16:2487-99.
9. Guo Y, Liu H, Xiao H, Yuan M, Liu Y, Sedlarik V, Chin WC, Liu J, Guo L*, Li C. Self-assembled Camptothecin derivatives - Curcuminoids conjugate for combinatorial chemo-photodynamic therapy to enhance anti-tumor efficacy. J Photochem Photobiol B. 2021; 215:112124.
10. Lei K, Yuan M, Zhou T, Ye Q, Zeng B, Zhou Q, Wei A, Guo L*. Research progress in the application of bile acid-drug conjugates: A "trojan horse" strategy. Steroids. 2021; 173:108879.
三）獲獎
1. 郭力，參附注射液品質(zhì)控制與產(chǎn)業(yè)化關(guān)鍵技術(shù)應(yīng)用，國家科技部，國家科學(xué)技術(shù)進(jìn)步獎，二等獎，2013
2. 郭力，烏頭類有毒中藥安全性評價模式的建立與示范，中國醫(yī)療保健國際交流促進(jìn)會，華夏醫(yī)學(xué)科技獎，二等獎，2013
3. 郭力，參附注射液的基礎(chǔ)、臨床與產(chǎn)業(yè)化關(guān)鍵問題研究，四川省人民政府，四川省科技進(jìn)步獎，一等獎，2012
4. 郭力，附子的系統(tǒng)研究與開發(fā)應(yīng)用，四川省人民政府，四川省科技進(jìn)步獎，一等獎，2010
5. 郭力，病證結(jié)合動物模型創(chuàng)制與中藥復(fù)方有效部位創(chuàng)新中藥尋找模式研究，四川省人民政府，四川省科技進(jìn)步獎，一等獎，2006