黃維
黃維，醫(yī)學博士/博士后，教授，博士研究生導師。四川省杰出青年資助計劃，世界中醫(yī)藥學會聯(lián)合會“中藥上市后再評價專業(yè)委員會”委員，四川省第二屆藥品安全專家委員會委員秘書。
研究方向：中藥活性成分機制及構(gòu)效關(guān)系研究；結(jié)合中藥多成分、多靶點協(xié)同作用特點，融合生物信息學、網(wǎng)絡藥理學、系統(tǒng)毒理學、手性合成、計算化學等多學科手段，研究中藥藥效物質(zhì)作用機制及構(gòu)效關(guān)系。
目前作為負責人，主持國家自然科學基金面上項目3項、國家自然科學基金青年基金、四川省重點研發(fā)項目、四川省杰出青年基金、中國博士后科學基金特別資助項目、中國博士后科學基金面上項目（一等）、教育部博士點基金、四川省科技廳基礎項目等課題；相關(guān)成果發(fā)表在Chemical Communications; Organic Chemistry Frontiers; Acta Pharmaceutica Sinica B; Advanced Synthesis & Catalysis等國內(nèi)外學術(shù)期刊上，共計收錄八十余篇，其中以第一作者或通訊作者發(fā)表SCI論文35篇；獲得國家授權(quán)發(fā)明專利7項；參編規(guī)劃教材6部，包括“十三五”規(guī)劃教材《藥物化學》、“十三五”規(guī)劃教材《天然藥物化學》。
獲四川省科技進步一等獎。入選首屆成都中醫(yī)藥大學“天府學者”學術(shù)榮譽體系：青年英才；入選第十三批四川省學術(shù)和技術(shù)帶頭人后備人選；指導學生參加教育部高等學校第九屆國際大學生“藥苑論壇”：獲創(chuàng)新成果獎、優(yōu)秀墻報獎；指導的碩士研究生多次獲得國家獎學金和學業(yè)獎學金。
聯(lián)系方式：huangwei@cdutcm.edu.cn
主持基金項目：
1.國家自然科學基金面上項目，鉤藤吲哚生物堿誘導線粒體自噬治療PD的分子網(wǎng)絡機制和立體異構(gòu)效應研究，2021/01/-2024/12，55萬元，負責人
2.國家自然科學基金面上項目，以配位化學關(guān)聯(lián)手性結(jié)構(gòu)特征探究中藥熟地黃通過自噬-溶酶體途徑治療帕金森病的物質(zhì)基礎，2018/01-2021/12，55萬元，負責人
3.國家自然科學基金面上項目，融合多層次化學結(jié)構(gòu)特征研究鉤吻中吲哚生物堿抗乳腺癌的構(gòu)效關(guān)系和作用機制，2016/01-2019/12，57萬元，負責人
4.國家自然科學基金青年項目，基于多靶標網(wǎng)絡調(diào)控研究青黛治療慢粒白血病的藥效物質(zhì)基礎和作用機制，2014/01-2016/12，23萬元，負責人
5.四川省重點研發(fā)項目，中藥調(diào)控細胞程序性死亡的活性物質(zhì)庫構(gòu)建和成藥性評價，2021/04-2023/03，100萬元，負責人
6.成都中醫(yī)藥大學一流學科項目，硫代二酮哌嗪類吲哚生物堿誘導腫瘤細胞自噬性死亡的分子網(wǎng)絡機制研究，2018/01-2022/12，100萬元，負責人
代表性成果：
1.Cui Ye, Nan Zhang, Qian Zhao, Xin Xie, Xiang Li, Hong-Ping Zhu, Cheng Peng*, Wei Huang*. Evodiamine alleviates lipopolysaccharide-induced pulmonary inflammation and fibrosis by activating apelin pathway. Phytotherapy Research. 2021, 1-12.
2.Shuai-Jiang Liu, Qing Mao, Ya-Jun Zhong, Jing Xue, Ben-Hong Chen, Qian Zhao*, Wei Huang*. Highly diastereoselective assembly of isoxazole and trifluoromethyl containing spiro[pyrrolidin-oxindoles] from N-2,2,2-trifluoroethylsubstituted isatin imines and styrylisoxazoles. Tetrahedron Letters, 2020,doi.org/10.1016/j.tetlet.2020.152687.
3.Hai-Jun Leng+, Yu-Ting Wang+, Xiang-Hong He+, Hou-Lin Xia,* Peng-Shuai Xu,Peng Xiang, Qing-Qing He, Gu Zhan,* Wei Huang*. Design and Efficient Synthesis of RalA Inhibitors Containing the Dihydro-α-carboline Scaffold. ChemMedChem, 2020, 15, 1-10.
4.Chen Fei-Yu, Li Xiang, Zhu Hong-Ping, Huang Wei*. Regulation of the Ras-Related Signaling Pathway by Small Molecules Containing an Indole Core Scaffold: a Potential Antitumor Therapy. Frontiers in Pharmacology, 2020, 11, 280.
5.Zhao Qian, Zhu Hong-Ping, Xie Xin, Mao Qing, Liu Yan-Qing, He Xiang-Hong, Peng Cheng, Jiang Qing-Lin*, Huang Wei*. Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways. International Journal of Molecular Science, 2020, 21, 1845.
6.Ren Wen, Zhao Qian, Yu Meng, Guo Li, Chang Hongmei, Jiang Xian, Luo Yonfu, Huang Wei*, He Gu*. Design and synthesis of novel spirooxindole–indenoquinoxaline derivatives as novel tryptophanyl-tRNA synthetase inhibitors. Molecular Diversity, 2019, 10.1007/s11030-019-10011-2.
7.Chen Can, Jiang Li, Zhang Min, Pan Xiaoli, Peng Cheng, Huang Wei *, Jiang Qinglin*. Isodunnianol alleviates doxorubicin-induced myocardial injury by activating protective autophagy. Food Function, 2019, 10, 2651-2657.
8.Ji Yan-Li, He Xiang-Hong, Peng Cheng *, Huang Wei*. Recent advances in the synthesis of C2-spiropseudoindoxyls. Organic & Biomolecular Chemistry, 2019, 17, 2850-2864.
9.Tang Xue, Zhu Hong-Ping, Zhou Jin, Chen Yang, Pan Xiao-Li, Guo Li, Li Jun-Long, Peng Cheng*, HuangWei*. Highly diastereoselective synthesis of cyclopropane-fused spiro-pseudoindoxyl derivatives through [2 + 1] annulation of 2-ylideneoxindoles and sulfonium bromides. Organic & Biomolecular Chemistry, 2018, 16, 8169-8174.
10.Li Xiang, Liu Yan-Qing, Kang Jing-Wen, Chen Fei-Yu, He Xi-Guo, Yuan Shan-Shan, Guo Li, Cheng Peng *, Huang Wei *. Synthesis of Vinylcyclopropane-Fused Pyrazolone Derivatives by Sulfur Ylide-Initiated 1,6-Michael Addition-Cyclization Reactions. European Journal of Organic Chemistry, 2018, 4723-4730.
11.Liu Yanqing, Ouyang Liang, Tan Ying, Tang Xue, Kang Jingwen, Wang Chunting, Zhu Yaning, Peng Cheng*, Huang Wei*. One-Pot Two-Step Organocatalytic Asymmetric Synthesis of Spirocyclic Piperidones via Wolff Rearrangement–Amidation-Michael- Hemiaminalization Sequence. Catalysts 2017, 7, 46.
12.Huang Wei, Cai Lulu, Chen Can, Xie Xin, Zhao Qiong*, Zhao Xing, Zhou Hong-yun, Han Bo, Peng Cheng*. Computational analysis of spiro-oxindole inhibitors of the MDM2-p53 interaction: insights and selection of novel inhibitors. Journal of Biomolecular Structure & Dynamics, 2016, 34, 341-351.
13.Wang Biao, Leng Hai-Jun, Yang Xue-Yuan, Han Bo, Rao Chao-Long, Liu Li, Peng Cheng*, Huang Wei*. Efficient synthesis of tetrahydronaphthalene- or isochroman-fused spirooxindoles using tandem reactions. Rsc Advances, 2015, 5, 88272-88276.
14.Zhao Qian, Han Bo, Wang Biao, Leng Hai-Jun, Peng Cheng*, Huang Wei*. Synthesis of functionalized gamma-lactones via a three-component cascade reaction catalyzed by consecutive N-heterocyclic carbene systems. Rsc Advances, 2015, 5, 26972-26976.
15.Li Xiang, Yang Lei, Peng Cheng*, Xie Xin, Leng Hai-Jun, Wang Biao, Tang Zheng-Wei, He Gu, Ouyang Liang, Huang Wei*, Han Bo*. Organocatalytic tandem Morita-Baylis-Hillman-Michael reaction for asymmetric synthesis of a drug-like oxa-spirocyclic indanone scaffold. Chemical Communications, 2013, 49, 8692-8694.