聯(lián)系電話：15198737656

郵    箱：hexiaofeng@cdutcm.edu.cn

一、 個(gè)人簡(jiǎn)介：

何小鳳，博士，副研究員，碩士生導(dǎo)師。2020年博士畢業(yè)于中科院昆明植物研究所藥物化學(xué)專業(yè)，2020年~2023年于中科院昆明植物研究所從事博士后研究工作。主要開展中藥及民族藥功效物質(zhì)的發(fā)現(xiàn)與創(chuàng)新應(yīng)用研究。代表性研究工作：（1）以活性篩選和LC-MS分析為導(dǎo)向，系統(tǒng)開展了藥食兩用中藥草果和草豆蔻的抗糖尿病活性成分研究，分離鑒定包括黃烷醇-單萜雜合體、二苯基庚烷-查爾酮雜合體、二苯基庚烷-二氫黃酮雜合體等多種結(jié)構(gòu)類型的新化合物150余個(gè)，發(fā)現(xiàn)70余個(gè)靶向PTP1B和α-葡萄糖苷酶且活性顯著優(yōu)于陽(yáng)性藥物的活性化合物，為擴(kuò)大兩種藥食同源中藥的應(yīng)用以及新型降血糖先導(dǎo)分子的發(fā)現(xiàn)提供了重要的化學(xué)和藥理學(xué)依據(jù)。（2）以抗肝癌活性為導(dǎo)向，結(jié)合LC-MS分析，從蒿屬中藥南牡蒿活性部位中分離鑒定9種新穎骨架類型的45個(gè)新倍半萜二聚體。其中11個(gè)化合物與臨床一線抗肝癌藥物活性相當(dāng)，且南牡蒿素G7安全性更優(yōu)，并通過(guò)WB、CETSA、ITC和SPR試驗(yàn)驗(yàn)證了其作用于PDGFRA靶點(diǎn)、影響AKT/STAT信號(hào)通路從而發(fā)揮抗肝癌活性，為新型抗肝癌藥物研發(fā)提供了結(jié)構(gòu)多樣的候選分子和重要的藥理學(xué)基礎(chǔ)。

主持國(guó)家自然科學(xué)基金青年基金、中國(guó)科學(xué)院特別研究助理、云南省博士后定向培養(yǎng)、中科院昆明植物研究所自主開放課題等項(xiàng)目。以第一作者（排名第一）在Signal Transduction and Targeted Therapy (中科院一區(qū)TOP, IF = 39.1)、Chinese Chemical Letters (一區(qū), IF = 9.1)、Journal of Agricultural and Food Chemistry (一區(qū), IF = 6.1)、Industrial Crops and Products (一區(qū), IF = 5.9)、Organic Chemistry Frontiers (一區(qū), IF = 5.4)、Bioorganic Chemistry (3篇, 一區(qū), IF = 5.1)、Phytochemistry、Chinese Journal of Chemistry、Organic & Biomolecular Chemistry等領(lǐng)域權(quán)威期刊發(fā)表SCI學(xué)術(shù)論文16篇，參與發(fā)表論文20余篇。

二、代表性成果（可含承擔(dān)項(xiàng)目、發(fā)表論文、論著、獲獎(jiǎng)等）

承擔(dān)項(xiàng)目（主持）

1. 國(guó)家自然科學(xué)基金委員會(huì)青年科學(xué)基金項(xiàng)目，82104040，南牡蒿和白蓮蒿中新穎抗肝癌活性倍半萜二聚體的快速發(fā)現(xiàn)和作用機(jī)制研究，2022.01至2024.12，30萬(wàn)元，主持。

2. 中國(guó)科學(xué)院特別研究助理資助項(xiàng)目，E12D9211Q1，南牡蒿和白蓮蒿中新穎倍半萜二聚體的抗肝癌活性成分發(fā)現(xiàn)，結(jié)構(gòu)優(yōu)化和作用機(jī)制研究，2020.09至2022.09，60萬(wàn)元，主持。

3. 云南省博士后定向培養(yǎng)資助項(xiàng)目，E131821261，南牡蒿和白蓮蒿中抗肝癌活性成分發(fā)現(xiàn)、結(jié)構(gòu)優(yōu)化和作用機(jī)制研究，2020.09至2022.09，16萬(wàn)元，主持。

4. 中國(guó)科學(xué)院昆明植物研究所自主開放課題，植物化學(xué)與西部植物資源持續(xù)利用國(guó)家重點(diǎn)實(shí)驗(yàn)室專項(xiàng)經(jīng)費(fèi)，2021.01至2023.12，15萬(wàn)元，主持

發(fā)表論文（第一作者排名第一）

1. Xiao-Feng He, Yun-Bao Ma, Tian-Ze Li, Ji-Jun Chen. Highly oxygenated guaiane-type sesquiterpene lactones from Artemisia sacrorum and their antihepatoma activity. Phytochemistry, 2024, 217, 113930. (中科院二區(qū), IF = 3.8)

2. Xiao-Feng He, Wen-Jjing Ma, Jing Hu, Tian-Ze Li, Chang-An Geng, Yun-Bao Ma, Meng-Fei Wang, Ke-Xin Yang, Xue-Mei Zhang, Ji-Jun Chen. Diverse structures and antihepatoma effect of sesquiterpenoid dimers from Artemisia eriopoda by AKT/STAT signaling pathway. Signal Transduction and Targeted Therapy, 2023, 8, 64. (中科院一區(qū), IF = 39.3)

3. Xiao-Feng He, Qi-Hao Li, Tian-Ze Li, Yun-Bao Ma, Wei Dong, Ke-Xin Yang, Chang-An Geng, Hao-Wei Zhang, Yuan Wang, Ji-Jun Chen. Artemeriopolides A?D, two types of sesquiterpenoid dimers with rare carbon skeletons from Artemisia eriopoda and their antihepatoma cytotoxicity. Organic Chemistry Frontiers, 2023. 10, 2635–2641. (中科院一區(qū), IF = 5.4)

4. Xiao-Feng He, Meng-Fei Wang, Tian-Ze Li, Yun-Bao Ma, Ji-Jun Chen. Artemannuols A–C, novel sesquiterpenoid-flavonol hybrids with antihepatoma activity from Artemisia annua. Organic & Biomolecular Chemistry, 2023, 21, 5451–5456. (中科院三區(qū), IF = 3.2)

5. Xiao-Feng He, Meng-Fei Wang, Yun-Bao Ma, Tian-Ze Li, Ji-Jun Chen. Artemeriosides A–F, the first examples of natural sesquiterpenoids substituted by a 6′-O-crontonyl β-glucopyranoside from Artemisia annua. Fitoterapia, 2023, 169, 105619. (中科院三區(qū), IF = 3.4)

6. Xiao-Feng He, Sheng-Li Wu, Ji-Jun Chen, Jing Hu, Xiao-Yan Huang, Tian-Ze Li, Xue-Mei Zhang, Yuan-Qiang Guo, Chang-An Geng. New diarylheptanoid dimers as GLP-1 secretagogues and multiple-enzyme inhibitors from Alpinia katsumadai. Bioorganic Chemistry, 2022, 120, 10563. (中科院一區(qū), IF = 5.1)

7. Xiao-Feng He, Ji-Jun Chen, Tian-Ze Li, Jing Hu, Xue-Mei Zhang; Chang-An Geng. Diarylheptanoid-chalcone hybrids with PTP1B and α-glucosidase dual inhibition from Alpinia katsumadai. Bioorganic Chemistry, 2021, 108, 104683. (中科院一區(qū), IF = 5.1)

8. Xiao-Feng He, Ji-Jun Chen, Xiao-Yan Huang, Jing Hu, Xu-Ke Zhang, Yuan-Qiang Guo, Xue-Mei Zhang, Chang-An Geng. The antidiabetic potency of Amomum tsao-ko and its active flavanols, as PTP1B selective and α-glucosidase dual inhibitors. Industrial Crops and Products, 2021, 160, 112908. (中科院一區(qū), IF = 5.9)

9. Xiao-Feng He, Ji-Jun Chen, Tian-Ze Li, Jing Hu, Xiao-Yan Huang, Xue-Mei Zhang, Yuan-Qiang Guo, Chang-An Geng. Diarylheptanoid-flavanone hybrids as multiple-target antidiabetic agents from Alpinia katsumadai. Chinese Journal of Chemistry, 2021, 39, 3051?3063. (中科院二區(qū), IF = 5.4)

10. Xiao-Feng He, Ji-Jun Chen, Tian-Ze Li, Jing Hu, Xu-Ke Zhang, Yuan-Qiang Guo, Xue-Mei Zhang, Chang-An Geng. Tsaokols A and B, unusual flavanol-monoterpenoid hybrids as α-glucosidase inhibitors from Amomum tsao-ko. Chinese Chemical Letters, 2020, 32, 1202–1205. (中科院一區(qū), IF = 9.1)

11. Xiao-Feng He, Ji-Jun Chen, Tian-Ze Li, Xu-Ke Zhang, Yuan-Qiang Guo, Xue-Mei Zhang, Jing Hu, Chang-An Geng. Nineteen new flavanol-fatty alcohol hybrids with α-glucosidase and PTP1B dual inhibition, one unusual type of antidiabetic constituents from Amomum tsao-ko. Journal of Agricultural and Food Chemistry, 2020, 68, 11434?11448. (中科院一區(qū), IF = 6.1)

12. Xiao-Feng He, Xu-Ke Zhang, Chang-An Geng, Jing Hu, Xue-Mei Zhang, Yuan-Qiang Guo, Ji-Jun Chen. Tsaokopyranols A–M, 2,6-epoxydiarylheptanoids from Amomum tsao-ko and their α-glucosidase inhibitory activity. Bioorganic Chemistry, 2020, 96, 103638. (中科院一區(qū), IF = 5.1)

13. Xiao-Feng He, Hui-Mei Wang, Chang-An Geng, Jing Hu, Xue-Mei Zhang, Yuan-Qiang Guo, Ji-Jun Chen. Amomutsaokols A–K, diarylheptanoids from Amomum tsao-ko and their α-glucosidase inhibitory activity. Phytochemistry, 2020, 177, 112418. (中科院二區(qū), IF = 3.8)

14. Xiao-Feng He, Chang-An Geng, Xiao-Yan Huang, Yun-Bao Ma, Xue-Mei Zhang, Ji-Jun Chen. Chemical constituents from Mentha haplocalyx Briq. (Mentha canadensis L.) and their α-glucosidase inhibitory activities. Natural Products and Bioprospecting, 2019, 9, 223–229.